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Recombinant Human ABHD12 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | ABHD12-1214H |
| Product Overview : | ABHD12 MS Standard C13 and N15-labeled recombinant protein (NP_001035937) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 44.9 kDa |
| AA Sequence : | MRKRTEPVAL EHERCAAAGS SSSGSAAAAL DADCRLKQNL RLTGPAAAEP RCAADAGMKR ALGRRKGVWL RLRKILFCVL GLYIAIPFLI KLCPGIQAKL IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEEDVTIGV WHTVPAVWWK NAQGKDQMWY EDALASSHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF FLDPITSSGI KFANDENVKH ISCPLLILHA EDDPVVPFQL GRKLYSIAAP ARSFRDFKVQ FVPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPEHQHTR TRPLEQKLIS EEDLAANDIL DYKDDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | ABHD12 abhydrolase domain containing 12 [ Homo sapiens (human) ] |
| Official Symbol : | ABHD12 |
| Synonyms : | ABHD12; abhydrolase domain containing 12; C20orf22, chromosome 20 open reading frame 22; monoacylglycerol lipase ABHD12; ABHD12A; BEM46L2; dJ965G21.2; DKFZP434P106; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12; PHARC; C20orf22; DKFZp434P106; |
| Gene ID : | 26090 |
| mRNA Refseq : | NM_001042472 |
| Protein Refseq : | NP_001035937 |
| MIM : | 613599 |
| UniProt ID : | Q8N2K0 |
◆ Recombinant Protein
| Abhd12-1467M | Recombinant Mouse Abhd12 Protein, Myc/DDK-tagged | +Inquiry |
| ABHD12-073H | Recombinant Human ABHD12 Protein, GST-Tagged | +Inquiry |
| ABHD12-418R | Recombinant Rat ABHD12 Protein | +Inquiry |
| ABHD12-262C | Recombinant Cynomolgus ABHD12 Protein, His-tagged | +Inquiry |
| ABHD12-4493Z | Recombinant Zebrafish ABHD12 | +Inquiry |
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◆ Lysates
| ABHD12-9HCL | Recombinant Human ABHD12 cell lysate | +Inquiry |
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ABHD4ABHD5ABHD1ABHD11ABHD12ABHD14BABHD15ABHD2ABHD3ABHD8ABHD10ABHD6ABHD12BABHD13ABHD14AAbhd16aAbhd16b
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