- Cynomolgus Monkey(1)
- Rhesus Macaque(1)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)(1)
Recombinant Human ABHD12 Protein, Myc/DDK-tagged, C13 and N15-labeled
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|Cat.No. :||ABHD12-1214H Optional Service: Optional requirements on this protein|
|Product Overview :||ABHD12 MS Standard C13 and N15-labeled recombinant protein (NP_001035937) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.|
|Description :||This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.|
|Molecular Mass :||44.9 kDa|
|AA Sequence :||MRKRTEPVAL EHERCAAAGS SSSGSAAAAL DADCRLKQNL RLTGPAAAEP RCAADAGMKR ALGRRKGVWL RLRKILFCVL GLYIAIPFLI KLCPGIQAKL IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEEDVTIGV WHTVPAVWWK NAQGKDQMWY EDALASSHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF FLDPITSSGI KFANDENVKH ISCPLLILHA EDDPVVPFQL GRKLYSIAAP ARSFRDFKVQ FVPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPEHQHTR TRPLEQKLIS EEDLAANDIL DYKDDDDKV|
|Purity :||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Stability :||Stable for 3 months from receipt of products under proper storage and handling conditions.|
|Storage :||Store at -80 centigrade. Avoid repeated freeze-thaw cycles.|
|Concentration :||50 μg/mL as determined by BCA|
|Storage Buffer :||100 mM glycine, 25 mM Tris-HCl, pH 7.3.|
|Gene Name :||ABHD12 abhydrolase domain containing 12 [ Homo sapiens (human) ]|
|Official Symbol :||ABHD12|
|Synonyms :||ABHD12; abhydrolase domain containing 12; C20orf22, chromosome 20 open reading frame 22; monoacylglycerol lipase ABHD12; ABHD12A; BEM46L2; dJ965G21.2; DKFZP434P106; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12; PHARC; C20orf22; DKFZp434P106;|
|Gene ID :||26090|
|mRNA Refseq :||NM_001042472|
|Protein Refseq :||NP_001035937|
|UniProt ID :||Q8N2K0|
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This gene is overexpressed in nasal epithelium and bone.
Lipase inhibitor for obesity treatment, Small Molecule, Anti-Obesity Agents, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity
Phospholipid catabolic process, Lipid metabolic process, and Protein depalmitoylation.
They are DPP9, HSCB, COASY, SLC39A4, and SRSF1.
Arachidonate production from DAG, Effects of PIP2 hydrolysis, and GPCR downstream signalling.
It can be determined by analysing ABHD12 mRNA expression in breast cancer tissues and healthy tissues, based on a series of research, we found that mRNA expression profile revealed that the ABHD12 transcript is highly expressed in tissues of patients with breast cancer compared to that expressed in healthy tissues adjacent to tumour.
Disruption of ABHD12 in mice leads to (i) accumulation of lyso-PS in the cerebellum breaching the homeostatic threshold, inducing continuous stimulation of the Purkinje neurons, leading to deregulated cerebellar activity and (ii) increased levels of microglial activation and inflammation. Accompanying this inflammatory response in mice are behavioral deficits, including sensorimotor defects and hearing loss.
Lysophosphatidylserine (i.e. ABHD12) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes, represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system.
Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract)
It is because this gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation
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