Recombinant Human ACKR2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ACKR2-1629H
• Product Overview: CCBP2 MS Standard C13 and N15-labeled recombinant protein (NP_001287) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 43.4 kDa
• AA Sequence: MAATASPQPLATEDADSENSSFYYY DYLDEVAFMLCRKDAVVSFGKVFLP VFYSLIFVLGLSGNLLLLMVLLRYV PRRRMVEIYLLNLAISNLLFLVTLP FWGISVAWHWVFGSFLCKMVSTLYT INFYSGIFFISCMSLDKYLEIVHAQ PYHRLRTRAKSLLLATIVWAVSLAV SIPDMVFVQTHENPKGVWNCHADFG GHGTIWKLFLRFQQNLLGFLLPLLA MIFFYSRIGCVLVRLRPAGQGRALK IAAALVVAFFVLWFPYNLTLFLHTL LDLQVFGNCEVSQHLDYALQVTESI AFLHCCFSPILYAFSSHRFRQYLKA FLAAVLGWHLAPGTAQASLSSCSES SILTAQEEMTGMNDLGERQSENYPN KEDVGNKSATRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ACKR2 atypical chemokine receptor 2 [ Homo sapiens (human) ]
• Official Symbol: ACKR2
• Synonyms: ACKR2; atypical chemokine receptor 2; D6; hD6; CCR9; CCBP2; CCR10; CMKBR9; atypical chemokine receptor 2; C-C chemokine receptor D6; CC-chemokine-binding receptor JAB61; chemokine (C-C motif) receptor 9; chemokine (C-C) receptor 9; chemokine receptor CCR-10; chemokine receptor CCR-9; chemokine receptor D6; chemokine-binding protein 2; chemokine-binding protein D6
• Gene ID: 1238
• mRNA Refseq: NM_001296
• Protein Refseq: NP_001287
• MIM: 602648
• UniProt ID: O00590