Recombinant Human ACSF2 protein, His-tagged
Cat.No. : | ACSF2-47H |
Product Overview : | Recombinant human ACSF2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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- Gene Information
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Description : | ACSF2 also known as Acyl-CoA synthetase family member 2. Acyl-CoA synthetases are a family of enzymes that catalyze the thioesterification of fatty acids with coenzymeA to form activated intermediates, which play a fundamental role in lipid metabolism and homeostasis of lipid-related processes. ACSF2 are required for complex lipid synthesis, energy production via beta-oxidation, protein acylation and fatty-acid dependent transcriptional regulation. ACSF2 are also necessary for fatty acid import into cells by the process of vectorial acylation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline pH 7.4 containing 10% glycerol |
Molecular Mass : | 66.1kDa (597aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSLSSREVD RMVSTPIGGL SYVQGCTKKH LNSKTVGQCL ETTAQRVPER EALVVLHEDV RLTFAQLKEE VDKAASGLLSIGLCKGDRLG MWGPNSYAWV LMQLATAQAG IILVSVNPAY QAMELEYVLK KVGCKALVFP KQFKTQQYYN VLKQICPEVE NAQPGALKSQ RLPDLTTVISVDAPLPGTLL LDEVVAAGST RQHLDQLQYN QQFLSCHDPI NIQFTSGTTG SPKGATLSHY NIVNNSNILG ERLKLHEKTP EQLRMILPNP LYHCLGSVAGTMMCLMYGAT LILASPIFNG KKALEAISRE RGTFLYGTPT MFVDILNQPD FSSYDISTMC GGVIAGSPAP PELIRAIINK INMKDLVVAY GTTENSPVTFAHFPEDTVEQ KAESVGRIMP HTEARIMNME AGTLAKLNTP GELCIRGYCV MLGYWGEPQK TEEAVDQDKW YWTGDVATMN EQGFCKIVGR SKDMIIRGGENIYPAELEDF FHTHPKVQEV QVVGVKDDRM GEEICACIRL KDGEETTVEE IKAFCKGKIS HFKIPKYIVF VTNYPLTISG KIQKFKLREQ MERHLNL |
Purity : | >95% by SDS - PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Absorbance at 280nm) |
Gene Name : | ACSF2 acyl-CoA synthetase family member 2 [ Homo sapiens ] |
Official Symbol : | ACSF2 |
Synonyms : | ACSF2; acyl-CoA synthetase family member 2; acyl-CoA synthetase family member 2, mitochondrial; ACSMW; FLJ20920; PPARG binding, long chain fatty acid acyl Co-A ligase like; AVYV493; |
Gene ID : | 80221 |
mRNA Refseq : | NM_025149 |
Protein Refseq : | NP_079425 |
MIM : | 610465 |
UniProt ID : | Q96CM8 |
Chromosome Location : | 17q21.33 |
Function : | ATP binding; ligase activity; nucleotide binding; |
Products Types
◆ Recombinant Protein | ||
ACSF2-49H | Recombinant Human ACSF2 Protein, His-tagged | +Inquiry |
Acsf2-50R | Recombinant Rat Acsf2 Protein, His-tagged | +Inquiry |
ACSF2-124R | Recombinant Rat ACSF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACSF2-270M | Recombinant Mouse ACSF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACSF2-18C | Recombinant Cynomolgus Monkey ACSF2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACSF2-9078HCL | Recombinant Human ACSF2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionACSF2 inhibitors have been proposed as a potential therapeutic strategy for the treatment of metabolic disorders, although further research is needed to validate this approach.
ACSF2 has a broad substrate specificity and can activate a range of long-chain fatty acids including palmitic acid, oleic acid, and arachidonic acid.
ACSF2 activates fatty acids by converting them into their acyl-CoA derivatives through the use of ATP and CoA.
ACSF2 has been shown to play a role in the cellular stress response by regulating the activation of AMPK and the expression of stress response genes.
ACSF2 has been shown to play a role in tumor growth and progression in several types of cancer, including colorectal cancer and hepatocellular carcinoma.
ACSF2 is highly expressed in the liver and also in other tissues such as the brain, heart, and muscle.
ACSF2 has been shown to play a role in the regulation of lipid droplet dynamics by regulating the activity of lipases and promoting the formation of lipid droplets.
Overexpression of ACSF2 has been shown to increase fatty acid oxidation and decrease fatty acid synthesis in hepatocytes.
ACSF2 has been shown to play a role in insulin sensitivity by regulating glucose uptake and lipid metabolism in skeletal muscle cells.
ACSF2 has been shown to regulate the production of inflammatory cytokines in macrophages and may play a role in the development of inflammatory diseases.
Customer Reviews (5)
Write a reviewSuper fast shipping and excellent customer service. Will definitely buy from again.
Great product! Really satisfied with the quality of the recombinant protein.
Wonderful product!
Overall, I highly recommend this recombinant protein and the manufacturer for their excellent product and service.
I was impressed with the strict quality control measures the manufacturer had in place to ensure consistent quality.
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