Recombinant Human ACVR1 Protein (T172-C509), His tagged
Cat.No. : | ACVR1-0159H |
Product Overview : | Recombinant Human 8His-TEV-ACVR1(T172-C509) (Q207E) Protein was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
Description : | Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein Length : | T172-C509 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | ACVR1 activin A receptor, type I [ Homo sapiens (human) ] |
Official Symbol : | ACVR1 |
Synonyms : | ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; FOP; TSRI; ACTRI; |
Gene ID : | 90 |
mRNA Refseq : | NM_001105 |
Protein Refseq : | NP_001096 |
MIM : | 102576 |
UniProt ID : | Q04771 |
Products Types
◆ Recombinant Protein | ||
Acvr1-814M | Recombinant Mouse Acvr1 Protein, MYC/DDK-tagged | +Inquiry |
ACVR1-527H | Active Recombinant Human ACVR1 Protein, His/Fc-tagged | +Inquiry |
ACVR1-0158H | Recombinant Human ACVR1 Protein (T172-C509), Tag Free | +Inquiry |
ACVR1-1022H | Recombinant Human ACVR1 Protein, MYC/DDK-tagged | +Inquiry |
ACVR1-274H | Recombinant Human ACVR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACVR1-2686MCL | Recombinant Mouse ACVR1 cell lysate | +Inquiry |
ACVR1-478HCL | Recombinant Human ACVR1 cell lysate | +Inquiry |
ACVR1-1305RCL | Recombinant Rat ACVR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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