Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ADAT2 Protein, GST-tagged

Cat.No. : ADAT2-2507H
Product Overview : Human DEADC1 full-length ORF ( ENSP00000356566, 1 a.a. - 144 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : ADAT2 (Adenosine Deaminase, TRNA Specific 2) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include hydrolase activity and tRNA-specific adenosine deaminase activity.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 42.5 kDa
AA Sequence : MVYNNEVVGKGRNEVNQTKNATRHA EMVAIDQVLDWCRQSGKSPSEVFEH TVLYVTVEPCIMCAAALRLMKIPLV VYGCQNERFGGCGSVLNIASADLPN TGRPFQCIPGYRAEEAVEMLKTFYK QENPNAPKSKVRKKECQKS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADAT2 adenosine deaminase, tRNA-specific 2 [ Homo sapiens ]
Official Symbol : ADAT2
Synonyms : ADAT2; adenosine deaminase, tRNA-specific 2; adenosine deaminase, tRNA specific 2, TAD2 homolog (S. cerevisiae) , DEADC1, deaminase domain containing 1; tRNA-specific adenosine deaminase 2; dJ20N2.1; TAD2; tRNA specific adenosine deaminase 2 homolog (S. cerevisiae); deaminase domain containing 1; deaminase domain-containing protein 1; tRNA-specific adenosine deaminase 2 homolog; adenosine deaminase, tRNA-specific 2, TAD2 homolog; tRNA-specific adenosine-34 deaminase subunit ADAT2; DEADC1; dJ20N2;
Gene ID : 134637
mRNA Refseq : NM_182503
Protein Refseq : NP_872309
MIM : 615388
UniProt ID : Q7Z6V5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (12)

Ask a question
Are there any limitations to the use of ADAT2 protein in medicine? 09/25/2022

One limitation of using ADAT2 protein in medicine is the potential off-target effects of RNA editing. RNA editing is a complex process, and manipulating ADAT2 could potentially result in unintended changes to RNA molecules that could cause harmful effects. Additionally, the specificity and efficacy of RNA editing therapies are still being studied, and more research is needed to understand how precisely ADAT2 and related proteins can target specific RNA sequences.

Is ADAT2 protein being researched in any clinical trials? 01/31/2022

As of now, there are no clinical trials specifically investigating ADAT2 protein. However, RNA editing and the ADAR enzyme complex are active areas of research for potential therapeutic applications in various diseases. As such, it is possible that ADAT2 and other components of the ADAR enzyme complex may be investigated in clinical trials in the future.

Is ADAT2 protein involved in any diseases or disorders? 01/27/2022

Yes, ADAT2 protein has been implicated in several diseases or disorders. For example, mutations in ADAT2 have been associated with certain neurological disorders, such as Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia with motor neuron disease (FTD-MND). Additionally, abnormalities in RNA editing have been linked to various types of cancer, and ADAT2 is thought to play a role in the dysregulation of RNA editing in certain types of cancer.

Are there any commercial applications for manipulating ADAT2 protein? 08/08/2021

There may be commercial applications for manipulating ADAT2 protein in the development of RNA editing therapies and diagnostics for diseases that involve RNA editing defects. Additionally, there may be applications for ADAT2 in basic research on RNA editing and related processes. However, more research is needed to fully understand the potential commercial applications of manipulating ADAT2 protein.

Are there any regulatory considerations for using ADAT2 protein in medicine or commercial applications? 05/01/2021

Yes, any medical or commercial applications of manipulating ADAT2 protein would be subject to regulatory oversight. Gene therapy and RNA editing technologies are subject to rigorous safety and efficacy testing before they can be approved for clinical use by regulatory agencies such as the FDA in the United States. Additionally, commercial applications of manipulating ADAT2 could be subject to patent law and other intellectual property regulations.

Can ADAT2 protein be used to develop new drugs? 04/30/2021

Yes, ADAT2 protein could potentially be a target for developing new drugs. As dysregulation of RNA editing is increasingly recognized as an important factor in various diseases, ADAT2 could be targeted to develop drugs that modulate RNA editing. By regulating RNA editing, it may be possible to correct underlying genetic defects and treat diseases such as cancer or neurodegenerative disorders.

How is ADAT2 protein produced and what is its structure? 08/01/2020

ADAT2 protein is produced through transcription and translation of the ADAT2 gene. The gene encodes the ADAT2 protein, which is then formed through folding of its amino acid sequence. ADAT2 is a member of the family of tRNA-specific adenosine deaminase (tadA) enzymes and shares homology with other members of this family. The crystal structure of ADAT2 has been solved which shows that its active site is composed of two subunits, ADAT2 and ADAT3, which work together to modify RNA transcripts.

Are there any known diseases or disorders that are associated with ADAT2 protein? 08/02/2019

There are no known human diseases specifically caused by mutations or deficiencies in ADAT2 protein. However, as ADAT2 is a component of the ADAR enzyme complex which is involved in RNA editing, defects in RNA editing have been linked to a variety of diseases such as neurological disorders, autoimmune diseases, and cancers. Therefore, defects in ADAR complex components, including ADAT2, may also contribute to these disease states.

How might ADAT2 protein be used in medical research? 09/25/2018

ADAT2 protein has potential applications in medical research, specifically related to RNA editing. In some studies, ADAT2 has been shown to be a critical component of the RNA editing machinery that is important for diseases such as cancer and epilepsy. Researchers are working to develop therapies that modulate RNA editing to treat these diseases, and ADAT2 may be a potential target for these therapies.

Can ADAT2 protein be used as a biomarker for any diseases or conditions? 08/17/2018

To date, there are no known diseases or conditions in which ADAT2 protein has been shown to be a useful biomarker. However, as research into RNA editing and its role in disease progresses, it is possible that ADAT2 or other components of the ADAR enzyme complex may be found to serve as biomarkers for certain diseases or conditions.

What applications could the manipulation of ADAT2 protein have in medicine? 08/13/2017

Manipulating ADAT2 protein could have various medical applications due to its role in regulating RNA editing. RNA editing has been implicated in neurological disorders, such as epilepsy and schizophrenia, and manipulating ADAT2 could provide a way to restore proper RNA editing and potentially improve symptoms. Additionally, RNA editing has been shown to play a role in cancer development and progression, and targeted manipulation of ADAT2 could help to correct RNA editing defects in cancer cells and improve the efficacy of existing therapies. Further research is needed to understand the full potential of manipulating ADAT2 in medicine.

Could ADAT2 protein manipulation be used for gene therapy? 09/11/2015

Yes, ADAT2 protein manipulation could be used as part of gene therapy. Gene therapy involves introducing genetic material into cells to treat or prevent disease, and RNA editing is one potential application of gene therapy. Manipulating ADAT2 could provide a precise way to target specific RNA sequences and correct genetic mutations that cause disease. However, further research on the safety and efficacy of gene therapy is needed before it can be widely used as a treatment option.

Customer Reviews (0)

Write a review

Ask a Question for All ADAT2 Products

Required fields are marked with *

My Review for All ADAT2 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends