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Recombinant Human ADCK2 Protein, GST-tagged

Cat.No. : ADCK2-322H
Product Overview : Human ADCK2 full-length ORF ( NP_443085.2, 1 a.a. - 626 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : ADCK2 (AarF Domain Containing Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 95.4 kDa
AA Sequence : MVAPWRVSVRVCLSHLRCFELRQGL SLLRPSECPRDARLCWLLLGTLPKV VSLCGDVGEGAPDVLSRRRVRCSGA AGAGPAESLPRAGPLGGVFLHLRLW LRAGALLVKFFPLLLLYPLTYLAPS VSTLWLHLLLKATETSGPTYIKLGQ WASTRRDLFSEAFCAQFSKLHVRVT PHPWTHTERFLRQAFGDDWGSILSF ENREPVGSGCVAQVYKAYANTAFLE TDSVQRLGRASCLPPFSHTGAVGGL RELFGYLGNGRKPPENLADQSFLER LLLPKADLVGSNAGVSRAQVPGHQP EATNLISVAVKVLHPGLLAQVHMDL LLMKIGSRVLGVLPGIKWLSLPEIV EEFEKLMVQQIDLRYEAQNLEHFQV NFRNVKAVKFPTPLRPFVTREVLVE TYEESVPVSSYQQAGIPVDLKRKIA RLGINMLLKMIFVDNFVHADLHPGN ILVQGANGLSSSQEAQLQQADICDT LVVAVPSSLCPLRLVLLDAGIVAEL QAPDLRNFRAVFMAVVMGQGQRVAE LILHHARASECRDVEGFKTEMAMLV TQARKNTITLEKLHVSSLLSSVFKL LMTHKVKLESNFASIVFAIMVLEGL GRSLDPKLDILEAARPFLLTGPVCP P
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADCK2 aarF domain containing kinase 2 [ Homo sapiens ]
Official Symbol : ADCK2
Synonyms : ADCK2; aarF domain containing kinase 2; uncharacterized aarF domain-containing protein kinase 2; MGC20727; putative ubiquinone biosynthesis protein AarF; AARF;
Gene ID : 90956
mRNA Refseq : NM_052853
Protein Refseq : NP_443085
UniProt ID : Q7Z695

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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What are the consequences of ADCK2 mutations? 11/25/2021

Mutations in ADCK2 are associated with various diseases, including primary and secondary CoQ10 deficiencies, cerebellar ataxia, and steroid-resistant nephrotic syndrome. These mutations can affect the enzyme's ability to phosphorylate the intermediate compound in the CoQ10 biosynthesis pathway, leading to reduced levels of CoQ10 in tissues and cells. As CoQ10 plays important roles in energy production and protection against oxidative stress, CoQ10 deficiency can result in a range of symptoms, including muscle weakness, neurological problems, and kidney dysfunction.

Can ADCK2 protein be used for biomarker development? 06/23/2021

Some studies have investigated ADCK2 protein levels as a potential biomarker for CoQ10 deficiency, but the results have been mixed and more research is needed to determine whether ADCK2 levels could be used for diagnostic or prognostic purposes. Additionally, ADCK2 mutations have been associated with several diseases, so testing for these mutations may be a useful diagnostic tool in certain populations.

Can ADCK2 protein be used to develop new drugs? 11/19/2020

While there are currently no specific drugs targeting ADCK2 protein, the regulation of the CoQ10 biosynthesis pathway and its involvement in various diseases suggest that ADCK2 protein may be a useful target for drug development. Compounds that can increase CoQ10 biosynthesis or protect against oxidative stress may be potential therapeutic agents for diseases associated with CoQ10 deficiency.

Are there any risks associated with the use of ADCK2 protein therapeutically? 07/20/2020

The use of ADCK2 protein as a therapeutic agent has not been extensively studied, so there may be potential risks and side effects that are not yet known.

How can ADCK2 protein be targeted for therapeutic interventions? 01/12/2019

There is currently no specific drug targeting ADCK2 protein for therapeutic interventions. However, CoQ10 supplementation is widely used to treat CoQ10 deficiency-related disorders, and some studies have investigated compounds that can increase CoQ10 biosynthesis or protect against oxidative stress as potential therapeutic agents. Modulating the expression or activity of other proteins involved in the CoQ10 biosynthesis pathway may also be a potential strategy for increasing CoQ10 levels in cells or tissues.

What are the potential therapeutic applications of ADCK2 protein? 08/01/2018

The potential therapeutic applications of ADCK2 protein are not well understood. However, ADCK2 protein has been linked to several metabolic pathways, including CoQ10 biosynthesis, suggesting that it may be a potential therapeutic target for conditions related to CoQ10 deficiency.

Can exercise affect ADCK2 protein levels? 05/21/2018

There is limited research on the effects of exercise on ADCK2 protein levels, but some studies have suggested that exercise may help maintain mitochondrial function and reduce oxidative stress, which could potentially affect ADCK2 expression. However, more research is needed to confirm these findings.

Are there any dietary interventions that can affect ADCK2 protein levels? 12/13/2017

The regulation of ADCK2 expression in the body is not yet fully understood, but some studies have suggested that dietary intake may play a role. For example, a diet high in fruits and vegetables, which are rich in antioxidants, may help protect against oxidative stress and maintain mitochondrial function, possibly affecting ADCK2 protein levels.

How is ADCK2 expression regulated in the body? 08/07/2017

The regulation of ADCK2 expression in the body is not yet fully understood. Some studies have suggested that ADCK2 expression may be regulated by a transcription factor called Nrf2, which is involved in the cellular stress response and plays a role in maintaining mitochondrial function. Other studies have found that ADCK2 expression may be affected by a variety of other factors, such as dietary intake, aging, and exercise, but more research is needed to confirm these findings.

What are the potential applications of ADCK2 protein? 12/25/2015

One potential application of ADCK2 protein is as a therapeutic target for the treatment of diseases associated with CoQ10 deficiency, such as primary and secondary CoQ10 deficiencies, cerebellar ataxia, and steroid-resistant nephrotic syndrome. In addition, ADCK2 protein levels or mutations may be useful biomarkers for diagnostic or prognostic purposes in certain populations.

Is there a diagnostic test for ADCK2 mutations? 11/21/2015

Yes, diagnostic tests are available for ADCK2 mutations. These tests can be used to identify mutations associated with diseases such as cerebellar ataxia and steroid-resistant nephrotic syndrome.

Are there any clinical trials underway that focus on ADCK2 protein? 10/09/2015

There are currently no clinical trials underway that focus on ADCK2 protein. However, there are ongoing studies investigating CoQ10 supplementation in various conditions, including heart disease and neurodegenerative disorders.

Can ADCK2 protein be used to diagnose CoQ10 deficiency? 02/05/2015

ADCK2 protein levels may provide indirect information about CoQ10 levels in the body, but it is not a direct diagnostic tool for CoQ10 deficiency. Diagnosis of CoQ10 deficiency usually requires specific tests that measure CoQ10 levels in blood or tissues.

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