Recombinant Human ADD3, His-tagged
Cat.No. : | ADD3-9415H |
Product Overview : | Recombinant Human ADD3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
Availability | September 20, 2024 |
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Description : | Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | C-term-343a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | ADD3 adducin 3 (gamma) [ Homo sapiens ] |
Official Symbol : | ADD3 |
Synonyms : | adducin 3 (gamma); ADDL; Adducin-like protein 70; gamma-adducin |
Gene ID : | 120 |
mRNA Refseq : | NM_019903.3 |
Protein Refseq : | NP_063968.1 |
MIM : | 601568 |
UniProt ID : | Q9UEY8 |
Chromosome Location : | 10q25.2 |
Function : | actin binding;calmodulin binding;metal ion binding;protein kinase C binding;structural constituent of cytoskeleton |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (2)
Write a reviewShows excellent performance in proximity ligation assays for protein-protein interaction studies.
Performs exceptionally well in protein crystallization experiments, improving crystal quality and yield.
Q&As (10)
Ask a questionModulating the expression or activity of ADD3 can impact cellular processes like cell adhesion, cytoskeletal organization, or membrane dynamics.
ADD3 regulates downstream signaling pathways or target molecules that contribute to its cellular functions.
ADD3 exhibits subcellular localization, and its localization may undergo dynamic changes or translocation.
Functional domains or motifs within ADD3 can be identified and characterized.
Post-translational modifications, such as phosphorylation or acetylation, occur on ADD3 and can influence its function.
ADD3 interacts with specific proteins or binding partners, and these interactions can be context-dependent.
The expression of ADD3 can be regulated during development or in response to specific stimuli.
Specific antibodies or probes can be developed to visualize the localization or dynamics of ADD3 in live cells or tissues.
There may exist small molecules or drugs that selectively modulate the activity or stability of ADD3.
The expression pattern of ADD3 varies across different tissues and cell types.
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