Recombinant Human ADD3 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human ADD3 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : ADD3-771H
Product Overview : ADD3 MS Standard C13 and N15-labeled recombinant protein (NP_001112) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 75.5 kDa
AA Sequence : MSSDASQGVI TTPPPPSMPH KERYFDRINE NDPEYIRERN MSPDLRQDFN MMEQRKRVTQ ILQSPAFRED LECLIQEQMK KGHNPTGLLA LQQIADYIMA NSFSGFSSPP LSLGMVTPIN DLPGADTSSY VKGEKLTRCK LASLYRLVDL FGWAHLANTY ISVRISKEQD HIIIIPRGLS FSEATASNLV KVNIIGEVVD QGSTNLKIDH TGFSPHAAIY STRPDVKCVI HIHTLATAAV SSMKCGILPI SQESLLLGDV AYYDYQGSLE EQEERIQLQK VLGPSCKVLV LRNHGVVALG ETLEEAFHYI FNVQLACEIQ VQALAGAGGV DNLHVLDFQK YKAFTYTVAA SGGGGVNMGS HQKWKVGEIE FEGLMRTLDN LGYRTGYAYR HPLIREKPRH KSDVEIPATV TAFSFEDDTV PLSPLKYMAQ RQQREKTRWL NSPNTYMKVN VPEESRNGET SPRTKITWMK AEDSSKVSGG TPIKIEDPNQ FVPLNTNPNE VLEKRNKIRE QNRYDLKTAG PQSQLLAGIV VDKPPSTMQF EDDDHGPPAP PNPFSHLTEG ELEEYKRTIE RKQQGLEENH ELFSKSFISM EVPVMVVNGK DDMHDVEDEL AKRVSRLSTS TTIENIEITI KSPEKIEEVL SPEGSPSKSP SKKKKKFRTP SFLKKNKKKE KVEATRTRPL EQKLISEEDL AANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : ADD3 adducin 3 [ Homo sapiens (human) ]
Official Symbol : ADD3
Synonyms : ADD3; adducin 3 (gamma); ADDL; CPSQ3; gamma-adducin; adducin 3 (gamma); adducin-like protein 70
Gene ID : 120
mRNA Refseq : NM_001121
Protein Refseq : NP_001112
MIM : 601568
UniProt ID : Q9UEY8

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