Recombinant Human ADGRB3 Protein (Ala25-Thr880), C-His-tagged

• Cat.No.: ADGRB3-0281H
• Product Overview: Recombinant human ADGRB3 (Ala25-Thr880) was fused with the C-terminal His tag and was expressed in Mammalian cells.

Specification

• Source: Mammalian cells
• Species: Human
• Tag: C-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 94.16 kDa
• Protein Length: Ala25-Thr880
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS or lyophilized from PBS.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: ADGRB3 adhesion G protein-coupled receptor B3 [ Homo sapiens (human) ]
• Official Symbol: ADGRB3
• Synonyms: ADGRB3; adhesion G protein-coupled receptor B3; BAI3; adhesion G protein-coupled receptor B3; brain-specific angiogenesis inhibitor 3; dJ91B17.1 (brain-specific angiogenesis inhibitor 3)
• Gene ID: 577
• mRNA Refseq: NM_001704
• Protein Refseq: NP_001695
• MIM: 602684
• UniProt ID: O60242

Reviews

11/26/2019

Shows good stability and compatibility with various sample types and buffers.

10/21/2017

Highly effective in detecting and quantifying the expression levels of recombinant proteins in protein expression analysis.

Q&As

Does genetic manipulation or knockout of ADGRB3 in experimental models alter neuronal or behavioral phenotypes?

Genetic manipulation or knockout of ADGRB3 in experimental models results in observable changes in neuronal or behavioral phenotypes, including [specific phenotypic alterations] or [specific behavioral changes].

Does pharmacological modulation of ADGRB3 activity impact neuronal function or related behavioral phenotypes?

Pharmacological modulation of ADGRB3 activity can impact neuronal function and related behavioral phenotypes, potentially through [specific mechanisms] affecting [specific processes or behaviors].

What is the role of ADGRB3 in synaptic transmission and plasticity, and how does it influence neurotransmitter release or receptor function?

ADGRB3 plays a role in synaptic transmission and plasticity through [specific mechanisms], influencing neurotransmitter release or receptor function.

Does ADGRB3 interact with other synaptic proteins or receptors, and how does this interaction affect neural signal transmission?

ADGRB3 interacts with [specific synaptic proteins or receptors], forming complexes that modulate [specific neural signal transmission processes], such as [specific signaling cascades or synaptic events].

Are there any identified genetic variations or mutations in the ADGRB3 gene associated with neurodevelopmental disorders or psychiatric diseases?

Several genetic variations or mutations associated with neurodevelopmental disorders or psychiatric diseases have been identified in the ADGRB3 gene, highlighting its potential role in these conditions.

What are the downstream signaling pathways activated by ADGRB3 and how do they impact cellular processes?

ADGRB3 activates specific downstream signaling pathways, such as [specific pathway], which play key roles in regulating [specific cellular processes].

How does ADGRB3 contribute to neural development or synaptic plasticity, and what are the underlying mechanisms?

ADGRB3 contributes to neural development and synaptic plasticity through specific mechanisms, such as [specific protein-protein interactions] or [specific intracellular signaling cascades] that influence [specific processes].

Are there known ligands or interacting partners that bind to the ADGRB3 protein and modulate its signaling activity?

The ADGRB3 protein interacts with specific ligands or interacting partners, leading to the activation or modulation of its signaling activity.

What is the cellular and subcellular localization pattern of the ADGRB3 protein across different cell types and tissues?

The ADGRB3 protein exhibits a specific cellular and subcellular localization pattern, with prominent expression in specific cell types or tissues.

How is the expression of ADGRB3 regulated under normal physiological conditions and in response to specific stimuli?

Under normal physiological conditions, the expression of ADGRB3 is tightly regulated through specific mechanisms and can be modulated in response to specific stimuli via relevant signaling pathways.