Recombinant Human ADSS1 Protein, His (Fc)-Avi-tagged

• Cat.No.: ADSS1-286H
• Product Overview: Recombinant Human ADSS1 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Human
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ADSS1 adenylosuccinate synthase 1 [ Homo sapiens (human) ]
• Official Symbol: ADSS1
• Synonyms: MPD5; ADSSL1
• Gene ID: 122622
• mRNA Refseq: NM_152328.5
• Protein Refseq: NP_689541.1
• MIM: 612498
• UniProt ID: Q8N142

Reviews

03/26/2021

Exploring protein-protein interactions involved in lipid metabolism.

10/31/2020

Determining protein-protein interaction interfaces using electron microscopy.

07/22/2020

Characterizing protein-protein interactions involved in autophagy pathways.

Q&As

How is the subcellular localization of ADSS1 protein regulated under normal physiological conditions or in response to specific stimuli?

The subcellular localization of ADSS1 protein is regulated under normal physiological conditions, with predominant cytoplasmic distribution, although it may undergo changes in response to specific cellular signals or stimuli.

What are the specific metabolic pathways or cellular processes in which ADSS1 protein is involved?

ADSS1 protein is primarily involved in the de novo synthesis of purine nucleotides and plays a crucial role in the purine biosynthesis pathway.

How is the enzymatic activity of ADSS1 protein measured or quantified in experimental assays?

The enzymatic activity of ADSS1 protein can be measured using assays that quantify the production or consumption of specific substrates or products involved in purine metabolism.

What are the structural features or domains of ADSS1 protein that contribute to its enzymatic activity and substrate specificity?

ADSS1 protein possesses specific structural features or domains that contribute to its enzymatic activity and substrate binding, ensuring its role in catalyzing purine biosynthesis reactions.

Are there any known post-translational modifications or regulatory factors that modulate the activity of ADSS1 protein?

Post-translational modifications, such as phosphorylation or acetylation, and regulatory factors like signaling pathways or transcription factors, may modulate the activity of ADSS1 protein.

Are there any genetic variations or mutations in the ADSS1 gene that affect the expression or function of ADSS1 protein?

Genetic variations or mutations in the ADSS1 gene can impact the expression or function of ADSS1 protein, potentially leading to disorders related to purine metabolism.

How does dysregulation or dysfunction of ADSS1 protein impact cellular metabolism and contribute to human diseases or disorders?

Dysregulation or dysfunction of ADSS1 protein can disrupt cellular metabolism, particularly in purine nucleotide production, and contribute to disorders associated with purine metabolism abnormalities.

Are there any experimental approaches, such as knockdown or overexpression studies, that have been employed to investigate the functional significance of ADSS1 protein in cellular or animal models?

Experimental approaches, such as knockdown or overexpression studies, have been employed to investigate the functional significance of ADSS1 protein in cellular or animal models, providing insights into its roles and potential therapeutic interventions.

What experimental techniques have been used to study the expression and localization of ADSS1 protein in cells or tissues?

Techniques such as immunofluorescence and immunohistochemistry have been used to study the expression and subcellular localization of ADSS1 protein in cells or tissues.

Can ADSS1 protein interact with other proteins or participate in protein complexes, and if so, what are their functional implications?

ADSS1 protein has the potential to interact with other proteins or participate in protein complexes, which may be involved in regulating purine biosynthesis or related cellular processes.