| Description : |
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
82.7 kDa |
| AA Sequence : |
MNVIDHVRDMAAAGLHSNVRLLSSL LLTMSNNNPELFSPPQKYQLLVYHA DSLFHDKEYRNAVSKYTMALQQKKA LSKTSKVRPSTGNSASTPQSQCLPS EIEVKYKMAECYTMLKQDKDAIAIL DGIPSRQRTPKINMMLANLYKKAGQ ERPSVTSYKEVLRQCPLALDAILGL LSLSVKGAEVASMTMNVIQTVPNLD WLSVWIKAYAFVHTGDNSRAISTIC SLEKKSLLRDNVDLLGSLADLYFRA GDNKNSVLKFEQAQMLDPYLIKGMD VYGYLLAREGRLEDVENLGCRLFNI SDQHAEPWVVSGCHSFYSKRYSRAL YLGAKAIQLNSNSVQALLLKGAALR NMGRVQEAIIHFREAIRLAPCRLDC YEGLIECYLASNSIREAMVMANNVY KTLGANAQTLTLLATVCLEDPVTQE KAKTLFDKALTQRPDYIKAVVKKAE LLSREQKYEDGIALLRNALANQSDC VLHRILGDFLVAVNEYQEAMDQYSI ALR |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
