| Description : |
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63.2 kDa |
| AA Sequence : |
MNVIDHVRDMAAAGLHSNVRLLSSL LLTMSNNNPELFSPPQKYQLLVYHA DSLFHDKEYRNAVSKYTMALQQKKA LSKTSKVRPSTGNSASTPQSQCLPS EIEVKYKMAECYTMLKQDKDAIAIL DGIPSRQRTPKINMMLANLYKKAGR ERPSVTSYKEVLRQCPLALDAILGL LSLSVKGAEVASMTMNVIQTVPNLD WLSVWIKAYAFVHTGDNSRAISTIC SLEKKSLLRDNVDLLGSLADLYFRA GDNKNSVLKFEQAQMLDLYLIKGMD VYGYLLAREGRLEDVENLGCRLFNI SDQHAEPWVVSGCHSFYSKRYSRAL YLGAKAIQLNSNSVQALLLKGAALR NMGRVQEAIIHFREAIRLAPCRLDC YEGLIECYLASNSIREAMVMANNVY KTLGANAQTLTLLATVCLEDPVTQE KAKTLLDKALTQRPDYIKAVVKKAE LLSREQKYEDGIALLRNALANQSDC VLHRILGDFLVAVNEYQEAMDQYSI ALSLDPNDQKSLEGMQKMEKEESPT DATQEEDVDDMEGSGEEGDLEGSDS EAAQWADQEQWFGMQTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
