Recombinant Human ANGPT2 Protein, N-FLAG-tagged

• Cat.No.: ANGPT2-34H
• Product Overview: Recombinant human Angiopoietin-2 fusion protein. This protein contains an N-terminal FLAG-tag followed by the oligomerization domain of COMP (a.a 28-72 of mouse COMP (Cartilage Oligomeric Matrix Protein, also designated thrombospondin 5); fused to amino acids 258-496(end) of human Angiopoietin-2.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Protein Length: 28-72;258-496 a.a.
• Description: This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome.
• Form: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
• Molecular Mass: 33 kDa
• AA Sequence: ANG2 258–496 (end), COMP 28–72
• Purity: 84%
• Usage: Research Use Only
• Storage: At least 6 months at -80 centigrade.
• Storage Buffer: Aqueous buffer solution.
• Shipping: -80 centigrade
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: ANGPT2 angiopoietin 2 [ Homo sapiens (human) ]
• Official Symbol: ANGPT2
• Synonyms: ANG2; AGPT2; LMPHM10
• Gene ID: 285
• mRNA Refseq: NM_001147.3
• Protein Refseq: NP_001138.1
• MIM: 601922
• UniProt ID: O15123