Description : |
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
205.6 kDa |
AA Sequence : |
MMNEDAAQKSDSGEKFNGSSQRRKR PKKSDSNASFLRAARAGNLDKVVEY LKGGIDINTCNQNGLNALHLAAKEG HVGLVQELLGRGSSVDSATKKGNTA LHIASLAGQAEVVKVLVKEGANINA QSQNGFTPLYMAAQENHIDVVKYLL ENGANQSTATEDGFTPLAVALQQGH NQAVAILLENDTKGKVRLPALHIAA RKDDTKSAALLLQNDHNADVQSKMM VNRTTESGFTPLHIAAHYGNVNVAT LLLNRGAAVDFTARNGITPLHVASK RGNTNMVKLLLDRGGQIDAKTRDGL TPLHCAARSGHDQVVELLLERGAPL LARTKNGLSPLHMAAQGDHVECVKH LLQHKAPVDDVTLDYLTALHVAAHC GHYRVTKLLLDKRANPNARALNGFT PLHIACKKNRIKVMELLVKYGASIQ AITESGLTPIHVAAFMGHLNIVLLL LQNGASPDVTNIRGETALHMAARAG QVEVVRCLLRNGALVDARAREEQTP LHIASRLGKTEIVQLLLQHMAHPDA ATTNGYTPLHISAREGQVDVASVLL EAGAAHSLATKKGFTPLHVAAKYGS LDVAKLLLQRRAAADSAGKNGLTPL HVAAHYDNQKVALLLLEKGASPHAT AKNGYTPLHIAAKKNQMQIASTLLN YGAETNIVTKQGVTPLHLASQEGHT DMVTLLLDKGANIHMSTKSGLTSLH LAAQEDKVNVADILTKHGADQDAHT KLGYTPLIVACHYGNVKMVNFLLKQ GANVNAKTKNGYTPLHQAAQQGHTH IINVLLQHGAKPNATTANGNTALAI AKRLGYISVVDTLKVVTEEVTTTTT TITEKHKLNVPETMTEVLDVSDEEG DDTMTGDGGEYLRPEDLKELGDDSL PSSQFLDGMNYLRYSLEGGRSDSLR SFSSDRSHTLSHASYLRDSAVMDDS VVIPSHQVSTLAKEAERNSYRLSWG TENLDNVALSSSPIHSGFLVSFMVD ARGGAMRGCRHNGLRIIIPPRKCTA PTRVTCRLVKRHRLATMPPMVEGEG LASRLIEVGPSGAQFLGKLHLPTAP PPLNEGESLVSRILQLGPPGTKFLG PVIVEIPHFAALRGKERELVVLRSE NGDSWKEHFCDYTEDELNEILNGMD EVLDSPEDLEKKRICRIITRDFPQY FAVVSRIKQDSNLIGPEGGVLSSTV VPQVQAVFPEGALTKRIRVGLQAQP MHSELVKKILGNKATFSPIVTLEPR RRKFHKPITMTIPVPKASSDVMLNG FGGDAPTLRLLCSITGGTTPAQWED ITGTTPLTFVNECVSFTTNVSARFW LIDCRQIQESVTFASQVYREIICVP YMAKFVVFAKSHDPIEARLRCFCMT DDKVDKTLEQQENFAEVARSRDVEV LEGKPIYVDCFGNLVPLTKSGQHHI FSFFAFKENRLPLFVKVRDTTQEPC GRLSFMKEPKSTRGLVHQAICNLNI TLPIYTKESESDQEQEEEIDMTSEK NPQDEQERIEERLAYIADHLGFSWT ELARELDFTEEQIHQIRIENPNSLQ DQSHALLKYWLERDGKHATDTNLVE CLTKINRMDIVHLMETNTEPLQERI SHSYAEIEQTITLDHSEGFSVLQEE LCTAQHKQKEEQAVSKESETCDHPP IVSEEDISVGYSTFQDGVPKTEGDS SATALFPQTHKEQVQQDFSGKMQDL PEESSLEYQQEYFVTTPGTETSETQ KAMIVPSSPSKTPEEVSTPAEEEKL YLQTPTSSERGGSPIIQEPEEPSEH REESSPRKTSLVIVESADNQPETCE RLDEDAAFEKGDDMPEIPPETVTEE EYIDEHGHTVVKKVTRKIIRRYVSS EGTEKEEIMVQGMPQEPVNIEEGDG YSKVIKRVVLKSDTEQSEDNNETRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |