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Recombinant Human ANKRD2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ANKRD2-5117H
Product Overview : ANKRD2 MS Standard C13 and N15-labeled recombinant protein (NP_001123453) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 36 kDa
AA Sequence : MAKAPSWAGVGALAYKAPEALWPAE AVMDGTMEDSEAVQRATALIEQRLA QEEENEKLRGDARQKLPMDLLVLED EKHHGAQSAALQKVKGQERVRKTSL DLRREIIDVGGIQNLIELRKKRKQK KRDALAASHEPPPEPEEITGPVDEE TFLKAAVEGKMKVIEKFLADGGSAD TCDQFRRTALHRASLEGHMEILEKL LDNGATVDFQDRLDCTAMHWACRGG HLEVVKLLQSHGADTNVRDKEGDTA LHDAVRLNRYKIIKLLLLHGADMMT KNLAGKTPTDLVQLWQADTRHALEH PEPGAEHNGLEGPNDSGRETPQPVP AQTRTRPLEQKLISEEDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ANKRD2 ankyrin repeat domain 2 [ Homo sapiens (human) ]
Official Symbol : ANKRD2
Synonyms : ANKRD2; ankyrin repeat domain 2 (stretch responsive muscle); ankyrin repeat domain-containing protein 2; ARPP; hArpp; ankyrin-repeat protein; skeletal muscle ankyrin repeat protein; MGC104314;
Gene ID : 26287
mRNA Refseq : NM_001129981
Protein Refseq : NP_001123453
MIM : 610734
UniProt ID : Q9GZV1

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Q&As (15)

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What are the potential implications of ANKRD2 dysfunction in heart diseases? 10/31/2022

Dysfunction of ANKRD2 has been associated with various heart diseases. For example, reduced expression or loss of function mutations in ANKRD2 have been found in patients with dilated cardiomyopathy, a condition characterized by a weakened and enlarged heart. ANKRD2 dysfunction can lead to impaired contractility, abnormal calcium signaling, and disruptions in the structural integrity of the sarcomere, all of which contribute to the development of heart disease. Understanding the specific mechanisms of ANKRD2 dysfunction can provide insights into the underlying causes of these diseases and may lead to the development of targeted therapies.

Can ANKRD2 be used as a therapeutic target for heart diseases? 10/12/2022

ANKRD2 shows promise as a potential therapeutic target for heart diseases. Its involvement in maintaining cardiac muscle integrity and function suggests that modulating its activity could have beneficial effects on heart health. However, further research is needed to fully understand the complex mechanisms of ANKRD2 and develop targeted therapies.

Is there any evidence linking ANKRD2 to arrhythmias? 07/19/2022

Yes, there is evidence linking ANKRD2 to arrhythmias. ANKRD2 dysfunction has been associated with an increased risk of developing atrial fibrillation, a common cardiac arrhythmia characterized by irregular and rapid atrial electrical activity. Studies have identified genetic variants and mutations in ANKRD2 that are associated with an increased susceptibility to atrial fibrillation. These variants may disrupt the normal function of ANKRD2 and contribute to abnormal electrical conduction in the heart, leading to arrhythmias.

Are there any other tissues or organs where ANKRD2 protein is expressed? 07/03/2022

While ANKRD2 protein is primarily expressed in the heart, it is also found in skeletal muscles, specifically in the fast-twitch muscle fibers.

Is ANKRD2 protein associated with any diseases? 05/05/2022

Mutations or dysregulation of ANKRD2 have been associated with several cardiovascular diseases, including dilated cardiomyopathy and hypertrophic cardiomyopathy. ANKRD2 is believed to play a role in maintaining the structural integrity of the cardiac muscle.

Are there any known genetic variants or mutations in the ANKRD2 gene? 03/29/2022

Several genetic variants and mutations in the ANKRD2 gene have been identified. Some of these variants are associated with an increased risk of developing cardiovascular diseases, such as dilated cardiomyopathy and atrial fibrillation. For example, a single nucleotide polymorphism (SNP) in the ANKRD2 gene, known as rs10824026, has been shown to be associated with an increased risk of dilated cardiomyopathy.

Is there any ongoing research on ANKRD2 protein? 02/07/2022

Yes, research on ANKRD2 protein is ongoing, particularly in the context of understanding its role in heart diseases. Scientists are exploring the molecular mechanisms through which ANKRD2 functions and how its dysregulation contributes to cardiac muscle disorders.

Are there any other diseases or conditions associated with ANKRD2 protein? 02/23/2021

While ANKRD2 is primarily linked to cardiovascular diseases, recent studies have also suggested its involvement in other conditions. For example, there is evidence that ANKRD2 may play a role in cancer. It has been found to be upregulated in certain types of cancers, including breast, lung, and ovarian cancer. ANKRD2 has been suggested to regulate various processes in cancer cells, such as growth, migration, and invasion. However, more research is needed to fully understand the involvement of ANKRD2 in these diseases.

Is ANKRD2 expressed in other organs or tissues besides the heart? 02/20/2020

Yes, ANKRD2 is expressed in other organs and tissues besides the heart. While it is most abundant in cardiac muscle cells, ANKRD2 has been detected in skeletal muscle, smooth muscle, and certain regions of the brain. In skeletal muscle, ANKRD2 is involved in muscle development and regeneration. It also plays a role in smooth muscle contraction and function. In the brain, ANKRD2 is thought to be involved in the regulation of neuronal development and synaptic plasticity. The specific functions of ANKRD2 in these organs and tissues are still being investigated.

Is ANKRD2 involved in the regulation of cardiac hypertrophy? 10/15/2019

Yes, ANKRD2 has been implicated in the regulation of cardiac hypertrophy. Cardiac hypertrophy refers to the enlargement of the heart muscle in response to various stimuli, such as increased workload or stress. ANKRD2 has been shown to play a role in balancing the growth and proliferation of cardiac muscle cells. It helps to prevent excessive hypertrophy by inhibiting the activity of certain signaling molecules that promote cell growth. Dysfunction of ANKRD2 can disrupt this balance, leading to abnormal cardiac hypertrophy, which is associated with heart disease.

Are there any known interacting partners or proteins that interact with ANKRD2? 08/23/2019

ANKRD2 interacts with various proteins involved in the regulation of muscle function, such as titin, myosin, and troponin I. These interactions contribute to the structural and functional roles of ANKRD2 in muscle cells.

Are there any known protein interactions or signaling pathways involving ANKRD2? 08/07/2019

Yes, ANKRD2 is known to interact with several proteins and be involved in various signaling pathways. One of the well-studied interactions of ANKRD2 is with the titin protein in cardiac muscle cells. ANKRD2 binds to a specific region of titin, called the N2B element, and helps regulate the stiffness and elasticity of the cardiac muscle. ANKRD2 also interacts with other components of the sarcomere, such as myosin binding protein C and myosin heavy chain, suggesting its involvement in the contractile function of the heart.

Have targeted therapies been developed for ANKRD2-related heart diseases? 07/29/2019

Currently, there are no targeted therapies specifically developed for ANKRD2-related heart diseases. However, the identification of ANKRD2 as a key player in cardiac function and its association with heart diseases has provided valuable insights for potential therapeutic interventions. Targeting the pathways and mechanisms affected by ANKRD2 dysfunction may offer future therapeutic strategies.

What are the specific functions of ANKRD2 in cardiac muscle cells? 01/15/2018

ANKRD2 has several functions in cardiac muscle cells. It helps maintain the structural integrity of the sarcomere, the basic contractile unit of the muscle. It interacts with titin, a large protein that plays a crucial role in muscle elasticity and force transmission. ANKRD2 also participates in the regulation of gene expression, controlling the expression of specific genes involved in muscle growth and development. It is involved in the modulation of calcium signaling, which is essential for muscle contraction. Additionally, ANKRD2 has been found to play a role in the control of cell size and proliferation in cardiac muscle cells.

How is the expression of ANKRD2 regulated? 06/16/2016

The expression of ANKRD2 is regulated by various factors. It is known to be regulated at the transcriptional level, with specific transcription factors binding to the promoter region of the ANKRD2 gene and controlling its expression. In cardiac muscle cells, ANKRD2 expression is also regulated by mechanical stretch and pressure, as well as by hormone signaling pathways. The precise mechanisms of ANKRD2 regulation are still being investigated.

Customer Reviews (4)

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Reviews
12/10/2022

    Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

    01/20/2020

      Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.

      04/29/2017

        Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.

        06/14/2016

          It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.

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