Recombinant Human Annexin A5, His-tagged

• Cat.No.: ANXA5-1430H
• Product Overview: Recombinant human full-length Annexin 5 Protein was expressed inE. colicells using a N-terminal His tag. MW=37kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Annexin 5 is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. In vitro studies have shown that Annexin 5 is a cellular protein which plays a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin. Through affinity assays Annexin 5 has been localized on cells that expressed phosphatidylserine on the cell surface, a feature found in apoptosis as well as other forms of cell death.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Publications:
  A novel affinity-based method for the isolation of highly purified extracellular vesicles. (2016)

Gene Information

• Gene Name: ANXA5 annexin A5 [ Homo sapiens ]
• Synonyms: ANXA5; annexin A5; PP4; ANX5; ENX2; anchorin CII; endonexin II; lipocortin V; placental anticoagulant protein I; Annexin-5; Annexin V; Lipocortin V; Endonexin II; Calphobindin I; Placental anticoagulant protein I; Placental anticoagulant protein 4; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha; CBP-I; PAP-I
• Gene ID: 308
• mRNA Refseq: NM_001154
• Protein Refseq: NP_001145
• UniProt ID: P08758
• Chromosome Location: 4q27
• MIM: 131230
• Function: calcium ion binding; calcium-dependent phospholipid binding; eukaryotic cell surface binding; phospholipase inhibitor activity; protein binding; receptor tyrosine kinase binding