Recombinant Human AP1S2, His-tagged
Cat.No. : | AP1S2-3546H |
Product Overview : | Recombinant human AP1S2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
- Specification
- Gene Information
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Cat. No. : | AP1S2-3546H |
Description : | AP1S2, also known as AP-1 complex subunit sigma-2, serves as the small subunit of AP-1 complex 1 and is a member of the adaptin protein family. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. |
Source : | E. coli. |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 0.1M NaCl, 2mM DTT |
Molecular weight : | 20.7 kDa (177aa), confirmed by MALDI-TOF |
Purity : | > 85% by SDS - PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | AP1S2 adaptor-related protein complex 1, sigma 2 subunit [ Homo sapiens ] |
Synonyms : | adaptor-related protein complex 1; sigma2 subunit; mental retardation, X-linked 59; SIGMA1B; MGC:1902; Adapter-related protein complex 1 sigma-1B subunit; Adaptor protein complex AP-1 sigma-1B subunit; AP-1 complex subunit sigma-2; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; Sigma 1B subunit of AP-1 clathrin; MRX59; Sigma-adaptin1B; Sigma1B-adaptin; OTTHUMP00000022980; AP1S2; OTTHUMP00000022981; DC22; OTTHUMP00000022982; adaptor protein complex AP-1 sigma-1B subunit ; clathrin adaptor complex AP1 sigma 1B subunit; golgi adaptor HA1/AP1 adaptin sigma 1B subunit; golgi adaptor HA1/AP1 adaptin sigma-1B subunit; adapter-related protein complex 1 sigma-1B subunit; clathrin assembly protein complex 1 sigma-1B small chain |
Gene ID : | 8905 |
mRNA Refseq : | NM_003916 |
Protein Refseq : | NP_003907 |
MIM : | 300629 |
UniProt ID : | P56377 |
Chromosome Location : | Xp22.2 |
Function : | Protein transporter activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionThe present study suggests that the AP1S2 may be involved in the regulation of cellular DNA replication and repair, but the specific mechanism needs to be further explored.
The abnormal expression of AP1S2 may be related to people's longevity, health, obesity and other aspects. But the relevant mechanism needs to be further explored.
The present study suggests that the AP1S2 may affect cell growth and development mainly through mechanisms such as cell proliferation and differentiation, DNA replication and repair. However, the specific signal transduction mechanism needs further study.
The AP1S2 is mainly associated with cancer and cell proliferation-related diseases.
The abnormal expression of AP1S2 in tumor is closely related to proliferation, invasion, metastasis and prognosis. Targeted therapies that target its expression may have a positive impact on tumor treatment.
There is insufficient evidence that the AP1S2 directly affects the health of the skeletal system. However, it is closely related to the regulation of cell growth and differentiation, and may have an impact on the maintenance and repair of the skeletal system.
The abnormal expression of AP1S2 is closely related to tumor invasion, metastasis and prognosis. It may affect the process of tumor metastasis through various mechanisms.
The current study suggests that the AP1S2 may be a potential target for tumor drug development, but the specific development and application need to be further explored.
The current study found that the abnormal expression of AP1S2 may be related to neurodegenerative diseases, but the specific mechanism needs to be further studied.
Current research evidence suggests that AP1S2 plays an important role in apoptosis and programmed death, but the specific regulatory mechanisms need to be further explored.
It has not yet been determined whether recombinant AP1S2 can be used as a marker of tumor prognosis, and relevant studies need to continue.
At present, there is insufficient evidence to show that the AP1S2 directly affects immunity. However, it is closely related to the regulation of cell growth and differentiation, so it may have an impact on the regulation of immunity.
There is insufficient evidence to show that AP1S2 has a direct impact on maternal and fetal health. However, it is closely related to the regulation of cell growth and differentiation, and may have an impact on embryonic development and maternal and child health.
The expression of AP1S2 may be influenced by genetic factors. The study of its gene regulation mechanism is helpful to better understand the regulatory role of AP1S2 and the pathogenesis of related diseases.
Recombinant AP1S2 protein is involved in the regulation of tumor cell proliferation, metastasis and prognosis, and its targeted therapy may inhibit tumor cell growth, invasion and metastasis through multiple mechanisms to improve patient prognosis.
Customer Reviews (3)
Write a reviewThe catalytic activity of AP1S2 is very strong, and it can play an excellent catalytic role even under extremely harsh conditions, and its stability is amazing.
Ideal for experiments or applications that require a high degree of repeatability.
AP1S2 have a wide range of applications and can be used in a variety of biological experiments.
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