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Recombinant Human AP1S2, His-tagged

Cat.No. : AP1S2-3546H
Product Overview : Recombinant human AP1S2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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  • Gene Information
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Cat. No. : AP1S2-3546H
Description : AP1S2, also known as AP-1 complex subunit sigma-2, serves as the small subunit of AP-1 complex 1 and is a member of the adaptin protein family. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors.
Source : E. coli.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 0.1M NaCl, 2mM DTT
Molecular weight : 20.7 kDa (177aa), confirmed by MALDI-TOF
Purity : > 85% by SDS - PAGE
Concentration : 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : AP1S2 adaptor-related protein complex 1, sigma 2 subunit [ Homo sapiens ]
Synonyms : adaptor-related protein complex 1; sigma2 subunit; mental retardation, X-linked 59; SIGMA1B; MGC:1902; Adapter-related protein complex 1 sigma-1B subunit; Adaptor protein complex AP-1 sigma-1B subunit; AP-1 complex subunit sigma-2; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; Sigma 1B subunit of AP-1 clathrin; MRX59; Sigma-adaptin1B; Sigma1B-adaptin; OTTHUMP00000022980; AP1S2; OTTHUMP00000022981; DC22; OTTHUMP00000022982; adaptor protein complex AP-1 sigma-1B subunit ; clathrin adaptor complex AP1 sigma 1B subunit; golgi adaptor HA1/AP1 adaptin sigma 1B subunit; golgi adaptor HA1/AP1 adaptin sigma-1B subunit; adapter-related protein complex 1 sigma-1B subunit; clathrin assembly protein complex 1 sigma-1B small chain
Gene ID : 8905
mRNA Refseq : NM_003916
Protein Refseq : NP_003907
MIM : 300629
UniProt ID : P56377
Chromosome Location : Xp22.2
Function : Protein transporter activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (15)

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Does AP1S2 participate in the regulation of DNA repair? 12/08/2022

The present study suggests that the AP1S2 may be involved in the regulation of cellular DNA replication and repair, but the specific mechanism needs to be further explored.

Which aspects of human survival are related to the expression of AP1S2 ? 11/19/2022

The abnormal expression of AP1S2 may be related to people's longevity, health, obesity and other aspects. But the relevant mechanism needs to be further explored.

What is the signaling mechanism of AP1S2 ? 09/23/2022

The present study suggests that the AP1S2 may affect cell growth and development mainly through mechanisms such as cell proliferation and differentiation, DNA replication and repair. However, the specific signal transduction mechanism needs further study.

Which diseases is the AP1S2 associated with? 05/05/2022

The AP1S2 is mainly associated with cancer and cell proliferation-related diseases.

What is the effect of AP1S2 on tumor therapy? 04/20/2022

The abnormal expression of AP1S2 in tumor is closely related to proliferation, invasion, metastasis and prognosis. Targeted therapies that target its expression may have a positive impact on tumor treatment.

Does AP1S2 affect the health of the skeletal system? 02/10/2022

There is insufficient evidence that the AP1S2 directly affects the health of the skeletal system. However, it is closely related to the regulation of cell growth and differentiation, and may have an impact on the maintenance and repair of the skeletal system.

What is the relationship between AP1S2 and tumor metastasis? 12/28/2021

The abnormal expression of AP1S2 is closely related to tumor invasion, metastasis and prognosis. It may affect the process of tumor metastasis through various mechanisms.

Is AP1S2 a potential drug target for cancer treatment? 08/31/2021

The current study suggests that the AP1S2 may be a potential target for tumor drug development, but the specific development and application need to be further explored.

Is recombinant AP1S2 associated with neurodegenerative diseases? 10/24/2020

The current study found that the abnormal expression of AP1S2 may be related to neurodegenerative diseases, but the specific mechanism needs to be further studied.

Is AP1S2 related to apoptosis and programmed death? 12/08/2019

Current research evidence suggests that AP1S2 plays an important role in apoptosis and programmed death, but the specific regulatory mechanisms need to be further explored.

Can AP1S2 be used as a marker of tumor prognosis? 12/02/2019

It has not yet been determined whether recombinant AP1S2 can be used as a marker of tumor prognosis, and relevant studies need to continue.

Does AP1S2 affect immunity? 10/13/2019

At present, there is insufficient evidence to show that the AP1S2 directly affects immunity. However, it is closely related to the regulation of cell growth and differentiation, so it may have an impact on the regulation of immunity.

Does AP1S2 affect the health of pregnant women and fetuses? 05/19/2019

There is insufficient evidence to show that AP1S2 has a direct impact on maternal and fetal health. However, it is closely related to the regulation of cell growth and differentiation, and may have an impact on embryonic development and maternal and child health.

Is the expression of AP1S2 influenced by genetic factors? 03/18/2019

The expression of AP1S2 may be influenced by genetic factors. The study of its gene regulation mechanism is helpful to better understand the regulatory role of AP1S2 and the pathogenesis of related diseases.

What is the mechanism of action of AP1S2 in tumor therapy? 02/03/2019

Recombinant AP1S2 protein is involved in the regulation of tumor cell proliferation, metastasis and prognosis, and its targeted therapy may inhibit tumor cell growth, invasion and metastasis through multiple mechanisms to improve patient prognosis.

Customer Reviews (3)

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Reviews
05/05/2021

    The catalytic activity of AP1S2 is very strong, and it can play an excellent catalytic role even under extremely harsh conditions, and its stability is amazing.

    07/02/2020

      Ideal for experiments or applications that require a high degree of repeatability.

      04/12/2020

        AP1S2 have a wide range of applications and can be used in a variety of biological experiments.

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