Recombinant Human APBA1 protein, GST-tagged

• Cat.No.: APBA1-666H
• Product Overview: Human APBA1 full-length ORF ( AAI56048.1, 1 a.a. - 837 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 92.1 kDa
• AA Sequence: MNHLEGSAEVEVTDEAAGGEVNESV EADLEHPEVEEEQQQPPQQQHYVGR HQRGRALEDLRAQLGQEEEERGECL ARSASTESGFHNHTDTAEGDVIAAA RDGYDAERAQDPEDESAYAVQYRPE AEEYTEQAEAEHAEATHRRALPNHL HFHSLEHEEAMNAAYSGYVYTHRLF HRGEDEPYSEPYADYGGLQEHVYEE IGDAPELDARDGLRLYEQERDEAAA YRQEALGARLHHYDERSDGESDSPE KEAEFAPYPRMDSYEQEEDIDQIVA EVKQSMSSQSLDKAAEDMPEAEQDL ERPPTPAGGRPDSPGLQAPAGQQRA VGPAGGGEAGQRYSKEKRDAISLAI KDIKEAIEEVKTRTIRSPYTPDEPK EPIWVMRQDISPTRDCDDQRPMDGD SPSPGSSSPLGAESSSTSLHPSDPV EASTNKESRKSLASFPTYVEVPGPC DPEDLIDGIIFAANYLGSTQLLSDK TPSKNVRMMQAQEAVSRIKMAQKLA KSRKKAPEGESQPMTEVDLFISTQR IKVLNADTQETMMDHPLRTISYIAD IGNIVVLMARRRMPRSNSQENVEAS HPSQDGKRQYKMICHVFESEDAQLI AQSIGQAFSVAYQEFLRANGINPED LSQKEYSDLLNTQDMYNDDLIHFSK SENCKDVFIEKQKGEILGVVIVESG WGSILPTVIIANMMHGGPAEKSGKL NIGDQIMSINGTSLVGLPLSTCQSI IKGLKNQSRVKLNIVRCPPVTTVLI RRPDLRYQLGFSVQNGIICSLMRGG IAERGGVRVGHRIIEINGQSVVATP HEKIVHILSNAVGEIHMKTMPAAMY RLLTAQEQPVYI
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 [ Homo sapiens ]
• Official Symbol: APBA1
• Synonyms: APBA1; amyloid beta (A4) precursor protein-binding, family A, member 1; MINT1; amyloid beta A4 precursor protein-binding family A member 1; D9S411E; X11; mint-1; adapter protein X11alpha; adaptor protein X11alpha; neuron-specific X11 protein; neuronal munc18-1-interacting protein 1; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); X11A; LIN10; X11ALPHA
• Gene ID: 320
• mRNA Refseq: NM_001163
• Protein Refseq: NP_001154
• MIM: 602414
• UniProt ID: Q02410