Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human APEX2 Protein, MYC/DDK-tagged

Cat.No. : APEX2-2309H
Product Overview : Recombinant human APEX2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
  • Specification
  • Gene Information
  • Related Products
Description : Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 57.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 [ Homo sapiens ]
Official Symbol : APEX2
Synonyms : APE2; APEXL2; XTH2; ZGRF2
Gene ID : 27301
mRNA Refseq : NM_014481
Protein Refseq : NP_055296
MIM : 300773
UniProt ID : Q9UBZ4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the detection principle of APEX2 ? 08/27/2022

The APEX2 enables the detection of proteins by producing oxidation products and forming a stain in a visible range.

What are the advantages of APEX2 s compared with other labeling techniques? 08/01/2022

Recombinant APEX2 proteins are more sensitive and stable than other labeling technologies, allowing for labeling and detection in a shorter time.

What are the advantages of APEX2 ? 04/05/2021

APEX2 has the characteristics of high sensitivity, high specificity and rapid response, which is suitable for a variety of research and therapeutic needs.

How to prepare APEX2 ? 02/28/2021

APEX2 can be expressed and purified by genetic engineering technology.

What is the mechanism of action of APEX2 ? 05/27/2020

The APEX2 applies detectable markers to the protein through oxidation reactions, enabling visual study of the target protein.

What is the research progress of APEX2 in cancer field? 10/19/2019

Recombinant APEX2 protein can be used as a tumor marker to help realize early diagnosis, treatment monitoring and prognosis assessment of cancer.

How to evaluate the effect of APEX2 ? 05/08/2019

The effect of APEX2 s can usually be evaluated by comparing markers such as labeling effect, specificity, and sensitivity.

What are the limitations of APEX2 ? 04/28/2019

The recombinant APEX2 protein may have errors under certain conditions due to its special oxidation reaction mechanism.

In addition to the field of cancer, does APEX2 have applications in other disease research? 02/03/2019

Yes, APEX2 also has application potential in neurodegenerative diseases, cardiovascular diseases and other fields.

What are the clinical applications of APEX2 ? 02/01/2019

The recombinant APEX2 protein can be used clinically in the fields of labeling targeted drugs, tumor therapy and biosensors.

Customer Reviews (3)

Write a review
Reviews
11/08/2021

    APEX2 produced by them has high expression and easy detection.

    03/29/2021

      Maximizes the use of energy and resources by optimizing the production process and equipment.

      05/23/2020

        The results are very consistent in each experiment or application, thanks to its high stability and reproducibility, which provides great convenience for follow-up studies.

        Ask a Question for All APEX2 Products

        Required fields are marked with *

        My Review for All APEX2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends