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Recombinant Human ARHGAP17 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ARHGAP17-6620H
Product Overview : ARHGAP17 MS Standard C13 and N15-labeled recombinant protein (NP_001006635) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA, RAC1, and CDC42.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 95.4 kDa
AA Sequence : MKKQFNRMKQLANQTVGRAEKTEVL SEDLLQIERRLDTVRSICHHSHKRL VACFQGQHGTDAERRHKKLPLTALA QNMQEASTQLEDSLLGKMLETCGDA ENQLALELSQHEVFVEKEIVDPLYG IAEVEIPNIQKQRKQLARLVLDWDS VRARWNQAHKSSGTNFQGLPSKIDT LKEEMDEAGNKVEQCKDQLAADMYN FMAKEGEYGKFFVTLLEAQADYHRK ALAVLEKTLPEMRAHQDKWAEKPAF GTPLEEHLKRSGREIALPIEACVML LLETGMKEEGLFRIGAGASKLKKLK AALDCSTSHLDEFYSDPHAVAGALK SYLRELPEPLMTFNLYEEWTQVASV QDQDKKLQDLWRTCQKLPPQNFVNF RYLIKFLAKLAQTSDVNKMTPSNIA IVLGPNLLWARNEGTLAEMAAATSV HVVAVIEPIIQHADWFFPEEVEFNV SEAFVPLTTPSSNHSFHTGNDSDSG TLERKRPASMAVMEGDLVKKESFGV KLMDFQAHRRGGTLNRKHISPAFQP PLPPTDGSTVVPAGPEPPPQSSRAE SSSGGGTVPSSAGILEQGPSPGDGS PPKPKDPVSAAVPAPGRNNSQIASG QNQPQAAAGSHQLSMGQPHNAAGPS PHTLRRAVKKPAPAPPKPGNPPPGH PGGQSSSGTSQHPPSLSPKPPTRSP SPPTQHTGQPPGQPSAPSQLSAPRR YSSSLSPIQAPNHPPPQPPTQATPL MHTKPNSQGPPNPMALPSEHGLEQP SHTPPQTPTPPSTPPLGKQNPSLPA PQTLAGGNPETAQPHAGTLPRPRPV PKPRNRPSVPPPPQPPGVHSAGDSS LTNTAPTASKIVTDSNSRVSEPHRS IFPEMHSDSASKDVPGRILLDIDND TESTALTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ARHGAP17 Rho GTPase activating protein 17 [ Homo sapiens (human) ]
Official Symbol : ARHGAP17
Synonyms : PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH1B; MSTP038; MSTP066; MSTP110
Gene ID : 55114
mRNA Refseq : NM_001006634
Protein Refseq : NP_001006635
MIM : 608293
UniProt ID : Q68EM7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there any known ARHGAP17 polymorphisms associated with phenotypic variations in humans? 09/20/2021

There is limited information on ARHGAP17 polymorphisms associated with phenotypic variations in humans. The genetic variations or single nucleotide polymorphisms (SNPs) within ARHGAP17 and their association with specific traits, diseases, or phenotypic variations have not been well-investigated. Further studies are necessary to understand the impact of ARHGAP17 polymorphisms on human phenotypes.

Is ARHGAP17 involved in cancer progression? 07/04/2021

While there is limited research on the specific role of ARHGAP17 in cancer, dysregulation of Rho GTPases and other GAP proteins has been implicated in cancer progression. Since ARHGAP17 negatively regulates RhoA, alterations in its expression or function may impact tumor cell behavior, invasion, and metastasis. Further studies are needed to explore the potential involvement of ARHGAP17 in cancer.

Are there any functional or regulatory interactions between ARHGAP17 and other GAP proteins? 04/21/2021

The specific functional or regulatory interactions between ARHGAP17 and other GAP proteins have not been extensively studied. However, as ARHGAP17 belongs to the GAP family, there could be potential interactions with other GAP proteins that regulate Rho GTPases. Further research is needed to explore these possible interactions.

Are there any known drugs or compounds that target ARHGAP17? 01/27/2020

Currently, there are no known drugs or compounds specifically targeted towards ARHGAP17. However, since ARHGAP17 regulates RhoA signaling, drugs targeted at RhoA or other downstream effectors may indirectly affect ARHGAP17 function. Therapeutic strategies that modulate RhoA activity could potentially impact ARHGAP17-mediated processes.

Can ARHGAP17 be a therapeutic target? 12/03/2019

Due to the limited understanding of ARHGAP17's function and its direct involvement in specific diseases, it is not currently considered a well-established therapeutic target. However, further research may uncover specific contexts where modulating ARHGAP17 activity could be beneficial, particularly in diseases related to abnormal Rho GTPase signaling.

Is there any association between ARHGAP17 and human diseases? 07/11/2018

Limited research has been conducted on the association of ARHGAP17 with human diseases. However, altered expression or mutations in Rho GTPases or other GAP proteins have been implicated in several diseases, including cancer, neurological disorders, and cardiovascular diseases. More studies are needed to determine if ARHGAP17 alterations contribute to disease development.

Customer Reviews (8)

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Reviews
03/21/2023

    They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ARHGAP17 protein in their studies.

    05/25/2022

      These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

      07/17/2021

        Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

        03/17/2021

          the manufacturer's support is crucial for researchers using ARHGAP17 protein in trials.

          12/02/2019

            Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.

            12/02/2018

              Trusting in its consistent results, I am able to embark on my research with assurance and optimism.

              09/26/2018

                the ARHGAP17 protein stands out for its exceptional quality, coupled with the outstanding technical support delivered by the manufacturer.

                04/27/2018

                  I enthusiastically recommend the ARHGAP17 protein to fellow researchers who seek an unparalleled product accompanied by dedicated customer assistance.

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