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Recombinant Human ASCL3 Protein, MYC/DDK-tagged

Cat.No. : ASCL3-2818H
Product Overview : Recombinant Human ASCL3 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
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Description : Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 20.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ASCL3 achaete-scute complex homolog 3 (Drosophila) [ Homo sapiens ]
Official Symbol : ASCL3
Synonyms : bHLHa42; HASH3; SGN1
Gene ID : 56676
mRNA Refseq : NM_020646
Protein Refseq : NP_065697
MIM : 609154
UniProt ID : Q9NQ33

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is ASCL3 involved in embryonic development? 08/04/2020

Yes, ASCL3 has been shown to play a role in embryonic development, particularly in the formation of the gastrointestinal tract.

Can ASCL3 be used as a diagnostic marker for gastrointestinal diseases? 10/09/2019

ASCL3 expression and its dysregulation have been proposed as potential diagnostic markers for certain gastrointestinal diseases. However, further research is needed to establish its clinical utility.

What are the molecular functions of ASCL3? 04/11/2017

ASCL3 acts as a transcription factor, binding to specific DNA sequences in the genome and regulating the expression of target genes involved in cellular differentiation and development.

What happens when ASCL3 is mutated or dysregulated? 05/15/2016

Mutations or dysregulation of ASCL3 can lead to various gastrointestinal diseases, including colorectal cancer and inflammatory bowel diseases.

Does ASCL3 interact with other proteins? 05/06/2016

Yes, ASCL3 can interact with several other proteins to regulate its activity and downstream signaling pathways. Some known interacting proteins include β-catenin, SMAD4, and p300.

Customer Reviews (3)

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Reviews
05/12/2022

    Choosing the ASCL3 protein from this manufacturer not only provides me with a superior product but also grants me access to unparalleled technical support.

    08/08/2021

      The manufacturer's extensive experience and expertise in the field of ASCL3 protein research make them a trusted partner.

      10/02/2016

        The manufacturer's commitment to customer satisfaction and their willingness to customize solutions based on specific experimental requirements is commendable.

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