Recombinant Human ASH1L protein, GST-tagged
Cat.No. : | ASH1L-47H |
Product Overview : | Recombinant Human ASH1L protein, fused with N-terminal GST tag was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | ASH1L is a large , multi-domain protein associated with actively transcribed regions of chromatin, ASH1L is the human homolog of Drosophila Ash1, a Trithorax group protein. Like its counterpart in Drosophila, ASH1L contains a SET histone methyltransferase domain and has been found to play a role in the regulation of Hox gene expression. Although the ASH1L SET domain has been shown in vitro to methylate histone peptides on lysine-4 of histone H3 (H3K4), ASH1L is an H3K36 methyltransferase both in vivo and in vitro with nucleosomes as substrate. Recruitment of ASH1L by the ncRNA DBE-T to the chromosome 4q35 locus associated with FSHD (facioscapulohumeral muscular dystrophy) leads to increased H3K36me2 and inappropriate gene derepression at the FSHD locus. In a possible positive feedback loop, ASH1L increases expression of DBE-T itself, suggesting ASH1L’s methyltransferase activity or its interaction with DBE-T as potential therapeutic targets for FSHD. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Form : | Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 150 mM NaCl, 1 mM TCEP, 10% (v/v) glycerol |
Molecular Mass : | 59.5 kDa |
Protein length : | 2022-2302 |
Storage : | Store at -80centigrade. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles. |
Gene Name : | ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) [ Homo sapiens ] |
Official Symbol : | ASH1L |
Synonyms : | ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila); histone-lysine N-methyltransferase ASH1L; ASH1; ASH1L1; huASH1; KMT2H; ASH1-like protein; lysine N-methyltransferase 2H; absent small and homeotic disks protein 1 homolog; probable histone-lysine N-methyltransferase ASH1L; FLJ10504; KIAA1420; |
Gene ID : | 55870 |
mRNA Refseq : | NM_018489 |
Protein Refseq : | NP_060959 |
MIM : | 607999 |
UniProt ID : | Q9NR48 |
Chromosome Location : | 1q22 |
Pathway : | Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem; |
Function : | DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity; zinc ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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