Recombinant Human ASH2L Protein (1-534 aa), His-SUMO-tagged

• Cat.No.: ASH2L-1146H
• Product Overview: Recombinant Human ASH2L Protein (1-534 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Transcription. Protein Description: Full Length of Isoform 3.

Specification

• Description: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hatopoiesis.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 76.2 kDa
• Protein length: 1-534 aa
• AA Sequence: MDTQAGSVDEENGRQLGEVELQCGI CTKWFTADTFGIDTSSCLPFMTNYS FHCNVCHHSGNTYFLRKQANLKEMC LSALANLTWQSRTQDEHPKTMFSKD KDIIPFIDKYWECMTTRQRPGKMTW PNNIVKTMSKERDVFLVKEHPDPGS KDPEEDYPKFGLLDQDLSNIGPAYD NQKQSSAVSTSGNLNGGIAAGSSGK GRGAKRKQQDGGTTGTTKKARSDPL FSAQRLPPHGYPLEHPFNKDGYRYI LAEPDPHAPDPEKLELDCWAGKPIP GDLYRACLYERVLLALHDRAPQLKI SDDRLTVVGEKGYSMVRASHGVRKG AWYFEITVDEMPPDTAARLGWSQPL GNLQAPLGYDKFSYSWRSKKGTKFH QSIGKHYSSGYGQGDVLGFYINLPE DTETAKSLPDTYKDKALIKFKSYLY FEEKDFVDKAEKSLKQTPHSEIIFY KNGVNQGVAYKDIFEGVYFPAISLY KSCTVSINFGPCFKYPPKDLTYRPM SDMGWGAVVEHTLADVLYHVETEVD GRRSPPWEP
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) [ Homo sapiens ]
• Official Symbol: ASH2L
• Synonyms: ASH2L; ASH2; ASH2L2; Bre2; ASH2L1
• Gene ID: 9070
• mRNA Refseq: NM_001105214
• Protein Refseq: NP_001098684
• MIM: 604782
• UniProt ID: Q9UBL3