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Recombinant Human ASPN Protein (33-380 aa), His-SUMO-tagged

Cat.No. : ASPN-2003H
Product Overview : Recombinant Human ASPN Protein (33-380 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length of Mature Protein.
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  • Gene Information
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Description : Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer,50% glycerol
Molecular Mass : 55.7 kDa
Protein length : 33-380 aa
AA Sequence : DMEDTDDDDDDDDDDDDDDEDNSLF PTREPRSHFFPFDLFPMCPFGCQCY SRVVHCSDLGLTSVPTNIPFDTRML DLQNNKIKEIKENDFKGLTSLYGLI LNNNKLTKIHPKAFLTTKKLRRLYL SHNQLSEIPLNLPKSLAELRIHENK VKKIQKDTFKGMNALHVLEMSANPL DNNGIEPGAFEGVTVFHIRIAEAKL TSVPKGLPPTLLELHLDYNKISTVE LEDFKRYKELQRLGLGNNKITDIEN GSLANIPRVREIHLENNKLKKIPSG LPELKYLQIIFLHSNSIARVGVNDF CPTVPKMKKSLYSAISLFNNPVKYW EMQPATFRCVLSRMSVQLGNFGM
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : ASPN asporin [ Homo sapiens ]
Official Symbol : ASPN
Synonyms : ASPN; asporin; FLJ20129; PLAP1; SLRR1C; OS3; PLAP-1;
Gene ID : 54829
mRNA Refseq : NM_001193335
Protein Refseq : NP_001180264
MIM : 608135
UniProt ID : Q9BXN1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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