Recombinant Human ATF2 Protein, His-tagged

• Cat.No.: ATF2-849H
• Product Overview: Recombinant Human ATF2 fused with His tag at C-terminal was expressed in Sf9 cells.

Specification

• Description: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene.
• Source: Sf9 cells
• Species: Human
• Tag: His
• Form: 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 55 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ATF2 activating transcription factor 2 [ Homo sapiens ]
• Official Symbol: ATF2
• Synonyms: ATF2; activating transcription factor 2; cAMP responsive element binding protein 2 , CREB2; cyclic AMP-dependent transcription factor ATF-2; CRE BP1; HB16; TREB7; CREB-2; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cAMP response element-binding protein CRE-BP1; cyclic AMP-responsive element-binding protein 2; cAMP responsive element binding protein 2, formerly; activating transcription factor 2 splice variant ATF2-var2; CREB2; CRE-BP1; MGC111558
• Gene ID: 1386
• mRNA Refseq: NM_001256090
• Protein Refseq: NP_001243019
• MIM: 123811
• UniProt ID: P15336