Recombinant Human B2M & HLA-A protein(NY-ESO-1)(SLLMWITQC), His-tagged

• Cat.No.: B2M & HLA-A-892H
• Product Overview: Recombinant Human HLA-A*0201 NY-ESO-1 complex Protein is produced by our Mammalian expression system and the target gene encoding (SLLMWITQC)&Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a 10His tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: (SLLMWITQC)&Ile21-Met119&Gly25-Ile308 (Ala269Val)
• Description: NY-ESO-1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. Optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells.
• Form: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH7.4.
• Molecular Mass: 55-60kDa, reducing conditions.
• Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
• Purity: Greater than 90% as determined by reducing SDS-PAGE.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
  Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
  It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Shipping: The product is shipped at ambient temperature.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: B2M beta-2-microglobulin [ Homo sapiens (human) ]
• Official Symbol: B2M; HLA-A
• Synonyms: MHC; MY-ESO-1; HLA-A*0201 NY-ESO-1 complex Protein
• Gene ID: 567
• mRNA Refseq: NM_004048.4
• Protein Refseq: NP_004039.1
• MIM: 109700
• UniProt ID: P61769