Recombinant Human BAG1

• Cat.No.: BAG1-26063TH
• Product Overview: Recombinant fragment, corresponding to amino acids 72-345 of Human Bag1 with N-terminal proprietary tag, 66kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 72-345 a.a.
• Description: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
• Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tu
• Form: Liquid
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM MOPS, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 BAG domain.Contains 1 ubiquitin-like domain.

Gene Information

• Gene Name: BAG1 BCL2-associated athanogene [ Homo sapiens ]
• Official Symbol: BAG1
• Synonyms: BAG1; BCL2-associated athanogene; BAG family molecular chaperone regulator 1
• Gene ID: 573
• mRNA Refseq: NM_001172415
• Protein Refseq: NP_001165886
• MIM: 601497
• Uniprot ID: Q99933
• Chromosome Location: 9p12
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem
• Function: chaperone binding; protein binding; receptor signaling protein activity