| Description : |
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
119.9 kDa |
| AA Sequence : |
MEPNDSTSTAVEEPDSLEVLVKTLD SQTRTFIVGAQMNVKEFKEHIAASV SIPSEKQRLIYQGRVLQDDKKLQEY NVGGKVIHLVERAPPQTHLPSGASS GTGSASATHGGGSPPGTRGPGASVH DRNANSYVMVGTFNLPSDGSAVDVH INMEQAPIQSEPRVRLVMAQHMIRD IQTLLSRMETLPYLQCRGGPQPQHS QPPPQPPAVTPEPVALSSQTSEPVE SEAPPREPMEAEEVEERAPAQNPEL TPGPAPAGPTPAPETNAPNHPSPAE YVEVLQELQRLESRLQPFLQRYYEV LGAAATTDYNNNHEGREEDQRLINL VGESLRLLGNTFVALSDLRCNLACT PPRHLHVVRPMSHYTTPMVLQQAAI PIQINVGTTVTMTGNGTRPPPTPNA EAPPPGPGQASSVAPSSTNVESSAE GAPPPGPAPPPATSHPRVIRISHQS VEPVVMMHMNIQDSGTQPGGVPSAP TGPLGPPGHGQTLGQQVPGFPTAPT RVVIARPTPPQARPSHPGGPPVSGT LQGAGLGTNASLAQMVSGLVGQLLM QPVLVAQGTPGMAPPPAPATASASA GTTNTATTAGPAPGGPAQPPPTPQP SMADLQFSQLLGNLLGPAGPGAGGS GVASPTITVAMPGVPAFLQGMTDFL QATQTAPPPPPPPPPPPPAPEQQTM PPPGSPSGGAGSPGGLGLESLSPEF FTSVVQGVLSSLLGSLGARAGSSES IAAFIQRLSGSSNIFEPGADGALGF FGALLSLLCQNFSMVDVVMLLHGHF QPLQRLQPQLRSFFHQHYLGGQEPT PSNIRMATHTLITGLEEYVRESFSL VQVQPGVDIIRTNLEFLQEQFNSIA AHVLHCTDSGFGARLLELCNQGLFE CLALNLHCLGGQQMELAAVINGRIR RMSRGVNPSLVSWLTTMMGLRLQVV LEHMPVGPDAILRYVRRVGDPPQPL PEEPMEVQGAERASPEPQRENASPA PGTTAEEAMSRGPPPAPEGGSRDEQ DGASAETEPWAAAVPPEWVPIIQQD IQSQRKVKPQPPLSDAYLSGMPAKR RKTMQGEGPQLLLSEAVSRAAKAAG ARPLTSPESLSRDLEAPEVQESYRQ QLRSDIQKRLQEDPNYSPQRFPNAQ RAFADDPTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
