Recombinant Human BCKDK, His-tagged

• Cat.No.: BCKDK-27438TH
• Product Overview: Recombinant fragment, corresponding to amino acids 39-412 of Human BCKDH kinase with an N terminal His tag; Predicted MWt 44 kDa.

Specification

• Description: Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex,the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Lyophilised:Reconstitute with 109 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: HVEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYA GRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFII GCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQL VRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDK TLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIE KWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLD YILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVD LIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRIS PLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQL QSLQGIGTDVYLRLRHIDGREESFRI
• Sequence Similarities: Belongs to the PDK/BCKDK protein kinase family.Contains 1 histidine kinase domain.
• Protein length: 39-412

Gene Information

• Gene Name: BCKDK branched chain ketoacid dehydrogenase kinase [ Homo sapiens ]
• Official Symbol: BCKDK
• Synonyms: BCKDK; branched chain ketoacid dehydrogenase kinase; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
• Gene ID: 10295
• mRNA Refseq: NM_005881
• Protein Refseq: NP_005872
• Uniprot ID: O14874
• Chromosome Location: 16p11.2
• Function: ATP binding; ATP binding; [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; kinase activity; kinase activity