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Recombinant Human BECN1 protein, His/MBP-tagged

Cat.No. : BECN1-295H
Product Overview : Recombinant Human BECN1(127-268 aa) fused with His/MBP tag was expressed in E. coli.
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Description : This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His/MBP
Form : Liquid in PBS
Protein length : 127-268 aa
Purity : SDS-PAGE >90%
Applications : WB Positive Control
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : BECN1 beclin 1, autophagy related [ Homo sapiens ]
Official Symbol : BECN1
Synonyms : BECN1; beclin 1, autophagy related; beclin 1 (coiled coil, moesin like BCL2 interacting protein); beclin-1; ATG6; ATG6 autophagy related 6 homolog (S. cerevisiae); VPS30; ATG6 autophagy related 6 homolog; coiled-coil myosin-like BCL2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin1;
Gene ID : 8678
mRNA Refseq : NM_003766
Protein Refseq : NP_003757
MIM : 604378
UniProt ID : Q14457

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does BECN1 play in cancer biology? 12/29/2022

BECN1 is involved in cancer, influencing both tumor suppression and survival.

How does BECN1 contribute to cellular homeostasis? 10/20/2022

It helps maintain cellular health by regulating the degradation and recycling of cellular components.

What is the primary role of BECN1 in autophagy? 09/23/2021

BECN1, a key autophagy protein, initiates the autophagic process, crucial for cellular waste disposal.

How does BECN1 interact with other autophagy-related proteins? 07/10/2019

BECN1 interacts with a network of autophagy proteins, coordinating the autophagic response.

What is the impact of altered BECN1 activity on neurodegenerative diseases? 12/12/2018

Altered BECN1 activity is linked to neurodegeneration, as autophagy is essential for neuronal health.

What potential therapeutic applications arise from targeting BECN1 in disease treatment? 02/12/2018

Targeting BECN1 could provide new treatments for cancer and neurodegenerative diseases by modulating autophagy.

How do genetic variations in BECN1 affect autophagy? 08/11/2017

Genetic mutations in BECN1 can lead to dysfunctional autophagy, affecting cell survival and health.

Customer Reviews (3)

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Reviews
09/15/2022

    Top-notch analysis, enhances research outcomes.

    02/11/2022

      Reliable data source, trusted for data accuracy.

      04/08/2018

        Expertise shines, a critical research resource.

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