| Description : |
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
94.3 kDa |
| AA Sequence : |
MNSTEFTEDVEEVLKSITVKVETEA EDAALDCSVNSRTSEKHSVDSVLTA LQDSSKRKQLVSDGLLDSVPGVKRR RLIPEALLAGMRNRENSSPCQGNGE QAGRGRSLGNVWPGEEEPCNDATTP SYKKPLYGISHKIMEKKNPPSGDLL NVYELFEKANASNSPSSLRLLNEPQ KRDCGSTGAGTDNDPNIYFLIQKMF YMLNTLTSNMSQLHSKVDLLSLEVS RIKKQVSPTEMVAKFQPPPEYQLTA AELKQIVDQSLSGGDLACRLLVQLF PELFSDVDFSRGCSACGFAAKRKLE SLHLQLIRNYVEVYYPSVKDTAVWQ AECLPQLNDFFSRFWAQREMEDSQP SGQVASFFEAEQVDPGHFLDNKDQE EALSLDRSSTIASDHVVDTQDLTEF LDEASSPGEFAVFLLHRLFPELFDH RKLGEQYSCYGDGGKQELDPQRLQI IRNYTEIYFPDMQEEEAWLQQCAQR INDELEGLGLDAGSEGDPPRDDCYD SSSLPDDISVVKVEDSFEGERPGRR SKKIWLVPIDFDKLEIPQPDFEVPG ADCLLSKEQLRSIYESSLSIGNFAS RLLVHLFPELFTHENLRKQYNCSGS LGKKQLDPSRIKLIRHYVQLLYPRA KNDRVWTLEFVGKLDERCRRRDTEQ RRSYQQQRKVHVPGPECRDLTSYAI NPERFREEFEGPPLPPERSSKDFCK IPLDELVVPSPDFPVPSPYLLSDKE VREIVQQSLSVGNFAARLLVRLFPE LFTAENLRLQYNHSGACNKKQLDPT RLRLIRHYVEAVYPVEKMEEVWHYE CIPSIDERCRRPNRKKCDILKKAKK VEKTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
