Recombinant Human BID Protein, His-tagged
Cat.No. : | BID-2006H |
Product Overview : | Recombinant Human BID Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Asp195) of human BID (Accession #NP_001187.1) fused with a 6×His tag at the C-terminus. |
- Specification
- Gene Information
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Description : | This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol. |
Protein length : | Met1-Asp195 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | > 90% as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | BID BH3 interacting domain death agonist [ Homo sapiens ] |
Official Symbol : | BID |
Synonyms : | BID; BH3 interacting domain death agonist; BH3-interacting domain death agonist; p22 BID; BID isoform Si6; BID isoform L(2); BID isoform ES(1b); desmocollin type 4; apoptic death agonist; Human BID coding sequence; FP497; MGC15319; MGC42355; |
Gene ID : | 637 |
mRNA Refseq : | NM_001196 |
Protein Refseq : | NP_001187 |
MIM : | 601997 |
UniProt ID : | P55957 |
Products Types
◆ Recombinant Protein | ||
BID-1032M | Recombinant Mouse BID Protein, His (Fc)-Avi-tagged | +Inquiry |
Bid-711M | Recombinant Mouse Bid Protein, MYC/DDK-tagged | +Inquiry |
Bid-4029M | Active Recombinant Mouse Bid protein(Met1-Asp195), His&GST-tagged | +Inquiry |
BID-218H | Recombinant Human BID Protein, GST-tagged | +Inquiry |
BID-3838H | Active Recombinant Human BID protein | +Inquiry |
◆ Lysates | ||
BID-8455HCL | Recombinant Human BID 293 Cell Lysate | +Inquiry |
BID-8456HCL | Recombinant Human BID 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionBID protein mainly plays a role in the process of apoptosis. It can regulate cell survival and death signaling by interacting with other members of the Bcl-2 family.
The expression level of BID protein can be detected by immunohistochemistry, western blotting, real-time quantitative PCR and other techniques. At the same time, the activity of BID protein can be assessed by detecting the level of phosphorylation of BID protein and the number of BID protein within cells.
During apoptosis, the BID protein is activated, forming complexes with other Bcl-2 family members, releasing cytochrome c, initiating a cascade of caspase enzymes, and ultimately leading to apoptosis.
The interaction between BID protein and other proteins is regulated by a variety of factors, including phosphorylation, methylation, acetylation and other modifications, as well as interactions with other proteins. These factors can affect the interaction between BID protein and other proteins, which in turn affects the regulatory process of apoptosis.
In clinical practice, the expression level of BID protein can be measured to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in some tumor diseases, measuring the expression level of BID protein can help doctors determine the type, stage, and prognosis of the disease, and guide the choice of treatment regimen.
Expression level of BID protein is regulated by a variety of factors, including gene transcription, translation, modification, and degradation. These factors can affect the expression level of BID protein, which in turn affects the survival and death signals of cells.
Customer Reviews (3)
Write a reviewActivity retention time is very long and can be maintained for a long time.
The detection method is very sensitive and can easily detect small amounts of protein.
Expression level and stability are good and will be repurchased.
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