Recombinant Human BLMH Protein (Met213-Trp447), His tagged

• Cat.No.: BLMH-0765H
• Product Overview: Recombinant human BLMH (Met213-Trp447) fused with His tag was expressed in E. coli.

Specification

• Description: The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 2S proteasome. Bleomycin (BLM), a clinically used glycopeptide anticancer agent. BLMH is an essential protectant against BLM-induced death and has an important role in neonatal survival and in maintaining epidermal integrity. Sequencing revealed several putative sites phosphorylated by different types of protein kinases, but no signal sequence, transmembrane domain, N-linked glycosylation site or DNA-binding motif.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 28.54 kDa
• Protein Length: Met213-Trp447
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: BLMH bleomycin hydrolase [ Homo sapiens (human) ]
• Official Symbol: BLMH
• Synonyms: BLMH; bleomycin hydrolase; BH; BLM hydrolase; BMH
• Gene ID: 642
• mRNA Refseq: NM_000386
• Protein Refseq: NP_000377
• MIM: 602403
• UniProt ID: Q13867