| Description : |
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Form : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
| Bio-activity : |
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: TopoIIa peptide. ATP: 200 uM. |
| Molecular Mass : |
56.9 kDa |
| AA Sequence : |
MLLRSAGKLNVGTKKEDGESTAPTP RPKVLRCKCHHHCPEDSVNNICSTD GYCFTMIEEDDSGLPVVTSGCLGLE GSDFQCRDTPIPHQRRSIECCTERN ECNKDLHPTLPPLKNRDFVDGPIHH RALLISVTVCSLLLVLIILFCYFRY KRQETRPRYSIGLEQDETYIPPGES LRDLIEQSQSSGSGSGLPLLVQRTI AKQIQMVKQIGKGRYGEVWMGKWRG EKVAVKVFFTTEEASWFRETEIYQT VLMRHENILGFIAADIKGTGSWTQL YLITDYHENGSLYDYLKSTTLDAKS MLKLAYSSVSGLCHLHTEIFSTQGK PAIAHRDLKSKNILVKKNGTCCIAD LGLAVKFISDTNEVDIPPNTRVGTK RYMPPEVLDESLNRNHFQSYIMADM YSFGLILWEVARRCVSGGIVEEYQL PYHDLVPSDPSYEDMREIVCIKKLR PSFPNRWSSDECLRQMGKLMTECWA HNPASRLTALRVKKTLAKMSESQDI KL |
| Usage : |
Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
