| Description : |
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
79.53 kDa |
| AA Sequence : |
KKEDGESTAPTPRPKVLRCKCHHHC PEDSVNNICSTDGYCFTMIEEDDSG LPVVTSGCLGLEGSDFQCRDTPIPH QRRSIECCTERNECNKDLHPTLPPL KNRDFVDGPIHHRALLISVTVCSLL LVLIILFCYFRYKRQETRPRYSIGL EQDETYIPPGESLRDLIEQSQSSGS GSGLPLLVQRTIAKQIQMVKQIGKG RYGEVWMGKWRGEKVAVKVFFTTEE ASWFRETEIYQTVLMRHENILGFIA ADIKGTGSWTQLYLITDYHENGSLY DYLKSTTLDAKSMLKLAYSSVSGLC HLHTEIFSTQGKPAIAHRDLKSKNI LVKKNGTCCIADLGLAVKFISDTNE VDIPPNTRVGTKRYMPPEVLDESLN RNHFQSYIMADMYSFGLILWEVARR CVSGGIVEEYQLPYHDLVPSDPSYE DMREIVCIKKLRPSFPNRWSSDECL RQMGKLMTECWAHNPASRLTALRVK KTFAKMSESQDIKL |
| Quality Control Test : |
12.5% SDS-PAGE Stained with Coomassie Blue. |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
