Recombinant Human BNIP3L Protein (1-219 aa), His-tagged

• Cat.No.: BNIP3L-1342H
• Product Overview: Recombinant Human BNIP3L Protein (1-219 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length.

Specification

• Description: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 25.9 kDa
• Protein length: 1-219 aa
• AA Sequence: MSSHLVEPPPPLHNNNNNCEENEQS LPPPAGLNSSWVELPMNSSNGNDNG NGKNGGLEHVPSSSSIHNGDMEKIL LDAQHESGQSSSRGSSHCDSPSPQE DGQIMFDVEMHTSRDHSSQSEEEVV EGEKEVEALKKSADWVSDWSSRPEN IPPKEFHFRHPKRSVSLSMRKSGAM KKGGIFSAEFLKVFIPSLFLSHVLA LGLGIYIGKRLSTPSASTY
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like [ Homo sapiens ]
• Official Symbol: BNIP3L
• Synonyms: BNIP3L; BNIP3a; Nix; NIP3L; NIX
• Gene ID: 665
• mRNA Refseq: NM_004331
• Protein Refseq: NP_004322
• MIM: 605368
• UniProt ID: O60238