Recombinant Human BPNT1 Protein, GST-tagged

• Cat.No.: BPNT1-315H
• Product Overview: Human BPNT1 full-length ORF ( NP_006076.3, 1 a.a. - 261 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntases physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 54.5 kDa
• AA Sequence: MASSNTVLMRLVASAYSIAQKAGMI VRRVIAEGDLGIVEKTCATDLQTKA DRLAQMSICSSLARKFPKLTIIGEE DLPSEEVDQELIEDSQWEEILKQPC PSQYSAIKEEDLVVWVDPLDGTKEY TEGLLDNVTVLIGIAYEGKAIAGVI NQPYYNYEAGPDAVLGRTIWGVLGL GAFGFQLKEVPAGKHIITTTRSHSN KLVTDCVAAMNPDAVLRVGGAGNKI IQLIEGKASAYVFASPGCKKWDTCA PEVILHAVGAS
• Quality Control Test: 12.5% SDS-PAGE Stained with Coomassie Blue.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: BPNT1 3(2), 5-bisphosphate nucleotidase 1 [ Homo sapiens ]
• Official Symbol: BPNT1
• Synonyms: BPNT1; 3(2), 5-bisphosphate nucleotidase 1; 3(2),5-bisphosphate nucleotidase 1; BPntase; PAP-inositol-1,4-phosphatase; bisphosphate 3-nucleotidase 1; PIP
• Gene ID: 10380
• mRNA Refseq: NM_006085
• Protein Refseq: NP_006076
• MIM: 604053
• UniProt ID: O95861