Recombinant Human BRD2 BRD2-27674TH

Recombinant Human BRD2

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Cat.No. : BRD2-27674TH Optional Service: Optional requirements on this protein
Product Overview : Recombinant fragment of Human BRD2 (amino acids 167-256) with N terminal proprietary tag; Predicted MWt 35.53 kDa including the tag.
Description : This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
Protein length : 90 amino acids
Molecular Weight : 35.530kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : QTLEKIFLQK VASMPQEEQE LVVTIPKNSH KKGAKLAALQ GSVTSAHQVP AVSSVSHTAL YTPPPEIPTT VLNIPHPSVI SSPLLKSLHS
Sequence Similarities : Contains 2 bromo domains.Contains 1 ET domain.
Gene Name : BRD2 bromodomain containing 2 [ Homo sapiens ]
Official Symbol : BRD2
Synonyms : BRD2; bromodomain containing 2; bromodomain-containing protein 2; D6S113E; FSRG1; KIAA9001; NAT; RING3;
Gene ID : 6046
mRNA Refseq : NM_005104
Protein Refseq : NP_005095
MIM : 601540
Uniprot ID : P25440
Chromosome Location : 6p21.3
Pathway : Regulation of retinoblastoma protein, organism-specific biosystem;
Function : protein serine/threonine kinase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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