Recombinant Human BRSK1 Protein (S2-P778), Tag Free
Cat.No. : | BRSK1-1174H |
Product Overview : | Recombinant Human GG-BRSK1(S2-P778 end) Protein was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
Description : | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. |
Source : | Insect cell |
Species : | Human |
Tag : | No tag |
Form : | Liquid |
Protein Length : | S2-P778 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | BRSK1 BR serine/threonine kinase 1 [ Homo sapiens (human) ] |
Official Symbol : | BRSK1 |
Synonyms : | BRSK1; BR serine/threonine kinase 1; serine/threonine-protein kinase BRSK1; KIAA1811; SAD1 kinase; SAD1 homolog; protein kinase SAD1A; brain-selective kinase 1; SadB kinase short isoform; BR serine/threonine-protein kinase 1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1; brain-specific serine/threonine-protein kinase 1; hSAD1; FLJ43009; |
Gene ID : | 84446 |
mRNA Refseq : | NM_032430 |
Protein Refseq : | NP_115806 |
MIM : | 609235 |
UniProt ID : | Q8TDC3 |
Products Types
◆ Recombinant Protein | ||
BRSK1-5370H | Recombinant Human BR Serine/Threonine Kinase 1, GST-tagged | +Inquiry |
BRSK1-678R | Recombinant Rat BRSK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
BRSK1-1175H | Recombinant Human BRSK1 Protein (S2-P778), GST tagged | +Inquiry |
BRSK1-1020R | Recombinant Rat BRSK1 Protein | +Inquiry |
BRSK1-27740TH | Recombinant Human BRSK1, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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