| Description : |
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
122.4 kDa |
| AA Sequence : |
MDTPENVLQMLEAHMQSYKGNDPLG EWERYIQWVEENFPENKEYLITLLE HLMKEFLDKKKYHNDPRFISYCLKF AEYNSDLHQFFEFLYNHGIGTLSSP LYIAWAGHLEAQGELQHASAVLQRG IQNQAEPREFLQQQYRLFQTRLTET HLPAQARTSEPLHNVQVLNQMITSK SNPGNNMACISKNQGSELSGVISSA CDKESNMERRVITISKSEYSVHSSL ASKVDVEQVVMYCKEKLIRGESEFS FEELRAQKYNQRRKHEQWVNEDRHY MKRKEANAFEEQLLKQKMDELHKKL HQVVETSHEDLPASQERSEVNPARM GPSVGSQQELRAPCLPVTYQQTPVN MEKNPREAPPVVPPLANAISAALVS PATSQSIAPPVPLKAQTVTDSMFAV ASKDAGCVNKSTHEFKPQSGAEIKE GCETHKVANTSSFHTTPNTSLGMVQ ATPSKVQPSPTVHTKEALGFIMNMF QAPTLPDISDDKDEWQSLDQNEDAF EAQFQKNVRSSGAWGVNKIISSLSS AFHVFEDGNKENYGLPQPKNKPTGA RTFGERSVSRLPSKPKEEVPHAEEF LDDSTVWGIRCNKTLAPSPKSPGDF TSAAQLASTPFHKLPVESVHILEDK ENVVAKQCTQATLDSCEENMVVPSR DGKFSPIQEKSPKQALSSHMYSASL LRLSQPAAGGVLTCEAELGVEACRL TDTDAAIAEDPPDAIAGLQAEWMQM SSLGTVDAPNFIVGNPWDDKLIFKL LSGLSKPVSSYPNTFEWQCKLPAIK PKTEFQLGSKLVYVHHLLGEGAFAQ VYEATQGDLNDAKNKQKFVLKVQKP ANPWEFYIGTQLMERLKPSMQHMFM KFYSAHLFQNGSVLVGELYSYGTLL NAINLYKNTPEKVMPQGLVISFAMR MLYMIEQVHDCEIIHGDIKPDNFIL GNGFLEQDDEDDLSAGLALIDLGQS IDMKLFPKGTIFTAKCETSGFQCVE MLSNKPWNYQIDYFGVAATVYCMLF GTYMKVKNEGGECKPEGLFRRLPHL DMWNEFFHVMLNIPDCHHLPSLDLL RQKLKKVFQQHYTNKIRALRNRLIV LLLECKRSRKTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
