Recombinant Human c-ERBB2

• Cat.No.: ERBB2-18H
• Product Overview: Recombinant Human c-erbB2 Protein (537-636aa), was expressed in E.coli without tag (purified via proprietary chromatographic techniques).​

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 537-636 aa
• Description: c-erbB-2 is a receptor tyrosine kinase of the c-erbB family. It is closely related instructure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.
• Physical Appearance: Sterile Filtered clear solution.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE.
• Formulation: c-erbB2 at 100 µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Application And Suggested Dilutions: • ELISA • Inhibition Assays • Western Blotting.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 37 kDa.
• Storage: Store vial at -20ºC to -80ºC. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.

Gene Information

• Gene Name: ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ]
• Synonyms: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NEU; NGL; HER2; TKR1; CD340; HER-2; HER-2/neu; ERBB2; erbB-2; herstatin; c-erb B2/neu protein; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; EC 2.7.10.1; p185erbB2; CD340 antigen ; MLN 19; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2
• Gene ID: 2064
• mRNA Refseq: NM_001005862
• Protein Refseq: NP_001005862
• MIM: 164870
• UniProt ID: P04626
• Chromosome Location: 17q11.2-q12; 17q21.1
• Pathway: Adherens junction; Bladder cancer; Calcium signaling pathway; Endometrial cancer; ErbB signaling pathway; Focal adhesion; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Axon guidance
• Function: ATP binding; ErbB-3 class receptor binding; Hsp90 protein binding; epidermal growth factor receptor activity; glycoprotein binding; growth factor binding; identical protein binding; nucleotide binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding; receptor signaling protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; ubiquitin protein ligase binding