Recombinant Human C-Myc Binding Protein, His-tagged

• Cat.No.: MYCBP-6874H
• Product Overview: Recombinant human MYCBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 14.1 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-103aa
• Description: MYCBP, also known as c-Myc binding protein, binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. It translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. It has also been shown to associate with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm, which suggests a role for MYCBP in spermatogenesis.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl,1mM DTT.
• Molecular Mass: 14.1 kDa (123aa), confirmed by MALDI-TOF.
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PNSALDFLKH HLGAATPENP EIELLRLELA EMKEKYEAIV EENKKLKAKL AQYEPPQEEK RAE
• Purity: >95% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: MYCBP c-myc binding protein [ Homo sapiens ]
• Official Symbol: MYCBP
• Synonyms: MYCBP; c-myc binding protein; C-Myc-binding protein; AMY 1; associate of myc 1; associate of myc-1; AMY-1; FLJ41056
• Gene ID: 26292
• mRNA Refseq: NM_012333
• Protein Refseq: NP_036465
• MIM: 606535
• UniProt ID: Q99417
• Chromosome Location: 1p33-p32.2
• Pathway: Notch signaling pathway, organism-specific biosystem
• Function: protein binding; transcription coactivator activity