Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human C9orf72 Protein, His-tagged

Cat.No. : C9orf72-2037H
Product Overview : Recombinant human C9orf72 protein, fused to His-tagged at N-terminus, was expressed in E. coli
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016].
Source : E. coli
Species : Human
Tag : His
Form : 25 mM Tris, pH 8.0, 500mM NaCl, 10% glycerol.
Molecular Mass : 24.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : C9orf72 chromosome 9 open reading frame 72 [ Homo sapiens ]
Official Symbol : C9orf72
Synonyms : ALSFTD; DENNL72; FTDALS; FTDALS1
Gene ID : 203228
mRNA Refseq : NM_145005.6
Protein Refseq : NP_659442
MIM : 614260

Products Types

◆ Recombinant Protein
C9orf72-0211H Recombinant Human C9orf72 Protein, GST-Tagged +Inquiry
C9orf72-2915H Recombinant Human C9orf72 protein, His-tagged +Inquiry

See All C9orf72 Recombinant Protein

Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All C9orf72 Products

Required fields are marked with *

My Review for All C9orf72 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends