| Description : |
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
65.4 kDa |
| AA Sequence : |
MDDFERRRELRRQKREEMRLEAERI AYQRNDDDEEEAARERRRRARQERL RQKQEEESLGQVTDQVEVNAQNSVP DEEAKTTTTNTQVEGDDEAAFLERL ARREERRQKRLQEALERQKEFDPTI TDASLSLPSRRMQNDTAENETTEKE EKSESRQERYEIEETETVTKSYQKN DWRDAEENKKEDKEKEEEEEEKPKR GSIGENQGEEKGTKVQAKREKLQED KPTFKKEEIKDEKIKKDKEPKEEVK SFMDRKKGFTEVKSQNGEFMTHKLK HTENTFSRPGGRASVDTKEAEGAPQ VEAGKRLEELRRRRGETESEEFEKL KQKQQEAALELEELKKKREERRKVL EEEEQRRKQEEADRKLREEEEKRRL KEEIERRRAEAAEKRQKMPEDGLSD DKKPFKCFTPKGSSLKIEERAEFLN KSVQKSSGVKSTHQAAIVSKIDSRL EQYTSAIEGTKSAKPTKPAASDLPV PAEGVRNIKSMWEKGNVFSSPTAAG TPNKETAGLKVGVSSRINEWLTKTP DGNKSPAPKPSDLRPGDVSSKRNLW EKQSVDKVTSPTKVTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
