Recombinant Human CANT1 Protein (Ile107-Phe400), His tagged

• Cat.No.: CANT1-1083H
• Product Overview: Recombinant human CANT1 (Ile107-Phe400) fused with His tag was expressed in E. coli.

Specification

• Description: CANT1 (calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yield AMP and inorganic phosphate. Two isoenzymes are found in commercial preparations from S. tuberosum. One with a higher ratio of substrate selectivity for ATP: ADP and another with no selectivity. It can also act on ADP and other nucleoside triphosphates and diphosphates with the general reaction being NTP -> NDP + Pi -> NMP + 2Pi. The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes are implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. CANT1 functions as a calcium-dependent nucleotidase with a preference for UDP. Defects in CANT1 are the cause of desbuquois dysplasia.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 33.15 kDa
• Protein Length: Ile107-Phe400
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CANT1 calcium activated nucleotidase 1 [ Homo sapiens (human) ]
• Official Symbol: CANT1
• Synonyms: CANT1; calcium activated nucleotidase 1; soluble calcium-activated nucleotidase 1; SCAN 1; SHAPY; Soluble Ca Activated Nucleotidase; isozyme 1; apyrase homolog; putative MAPK-activating protein PM09; putative NF-kappa-B-activating protein 107; soluble Ca-activated nucleotidase, isozyme 1; soluble calcium-activated nucleotidase SCAN-1; Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification; DBQD; SCAN1; SCAN-1
• Gene ID: 124583
• mRNA Refseq: NM_001159772
• Protein Refseq: NP_001153244
• MIM: 613165
• UniProt ID: Q8WVQ1