| Description : |
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
GST |
| Form : |
The purified protein was resolved in 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 15%glycerol. |
| Protein length : |
235-533aa |
| AA Sequence : |
FAYPMPFCDRWGKLPLSPKQKTTFS KWVRPEDLTNNPTMIYTVSSFSIKQ TIVSDCSFVASLAISAAYERRFNKK LITGIIYPQNKDGEPEYNPCGKYMV KLHLNGVPRKVIIDDQLPVDHKGEL LCSYSNNKSELWVSLIEKAYMKVMG GYDFPGSNSNIDLHALTGWIPERIA MHSDSQTFSKDNSFRMLYQRFHKGD VLITASTGMMTEAEGEKWGLVPTHA YAVLDIREFKGLRFIQLKNPWSHLR WKGRYSENDVENWTPELQKYLNFDP RTAQKIDNGIFWISWDDLCQYYDV |
| Storage : |
Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months. Avoid freeze thaw cycles. |
| Shipping : |
The product is shipped with ice packs. Upon receipt, store it immediately at -20 centigrade to -80 centigrade. |
