Recombinant Human CAPNS1 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: CAPNS1-384H
• Product Overview: CAPNS1 MS Standard C13 and N15-labeled recombinant protein (NP_001003962) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 28.8 kDa
• AA Sequence: MFLVNSFLKGGGGGGGGGGGLGGGL GNVLGGLISGAGGGGGGGGGGGGGG GGGGGGTAMRILGGVISAISEAAAQ YNPEPPPPRTHYSNIEANESEEVRQ FRRLFAQLAGDDMEVSATELMNILN KVVTRHPDLKTDGFGIDTCRSMVAV MDSDTTGKLGFEEFKYLWNNIKRWQ AIYKQFDTDRSGTICSSELPGAFEA AGFHLNEHLYNMIIRRYSDESGNMD FDNFISCLVRLDAMFRAFKSLDKDG TGQIQVNIQEWLQLTMYSTRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CAPNS1 calpain, small subunit 1 [ Homo sapiens (human) ]
• Official Symbol: CAPNS1
• Synonyms: CAPNS1; calpain, small subunit 1; CAPN4; calpain small subunit 1; 30K; CANP; CANPS; CDPS; CANP small subunit; calpain regulatory subunit; calpain, small polypeptide; calpain 4, small subunit (30K); calcium-dependent protease, small subunit; calcium-dependent protease small subunit 1; calcium-activated neutral proteinase small subunit; CSS1; CALPAIN4
• Gene ID: 826
• mRNA Refseq: NM_001003962
• Protein Refseq: NP_001003962
• MIM: 114170
• UniProt ID: P04632