| Description : |
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
113.1 kDa |
| AA Sequence : |
MGELCRRDSALTALDEETLWEMMES HRHRIVRCICPSRLTPYLRQAKVLC QLDEEEVLHSPRLTNSAMRAGHLLD LLKTRGKNGAIAFLESLKFHNPDVY TLVTGLQPDVDFSNFSGLMETSKLT ECLAGAIGSLQEELNQEKGQKEVLL RRCQQLQEHLGLAETRAEGLHQLEA DHSRMKREVSAHFHEVLRLKDEMLS LSLHYSNALQEKELAASRCRSLQEE LYLLKQELQRANMVSSCELELQEQS LRTASDQESGDEELNRLKEENEKLR SLTFSLAEKDILEQSLDEARGSRQE LVERIHSLRERAVAAERQREQYWEE KEQTLLQFQKSKMACQLYREKVNAL QAQVCELQKERDQAYSARDSAQREI SQSLVEKDSLRRQVFELTDQVCELR TQLRQLQAEPPGVLKQEARTREPCP REKQRLVRMHAICPRDDSDCSLVSS TESQLLSDLSATSSRELVDSFRSSS PAPPSQQSLYKRVAEDFGEEPWSFS SCLEIPEGDPGALPGAKAGDPHLDY ELLDTADLPQLESSLQPVSPGRLDV SESGVLMRRRPARRILSQVTMLAFQ GDALLEQISVIGGNLTGIFIHRVTP GSAADQMALRPGTQIVMVDYEASEP LFKAVLEDTTLEEAVGLLRRVDGFC CLSVKVNTDGYKRLLQDLEAKVATS GDSFYIRVNLAMEGRAKGELQVHCN EVLHVTDTMFQGCGCWHAHRVNSYT MKDTAAHGTIPNYSRAQQQLIALIQ DMTQQCTVTRKPSSGGPQKLVRIVS MDKAKASPLRLSFDRGQLDPSRMEG SSTCFWAESCLTLVPYTLVWPHRPA RPRPVLLVPRAVGKILSEKLCLLQG FKKCLAEYLSQEEYEAWSQRGDIIQ EGEVSGGRCWVTRHAVESLMEKNTH ALLDVQLDSVCTLHRMDIFPIVIHV SVNEKMAKKLKKGLQRLGTSEEQLL EAARQEEGDLDRAPCLYSSLAPDGW SDLDGLLSCVRQAIADEQKKVVWTE QSPRTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
