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Recombinant Human CASP3 protein, His/MBP-tagged

Cat.No. : CASP3-293H
Product Overview : Recombinant Human CASP3(1-113 aa) fused with His/MBP tag was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Source : E. coli
Species : Human
Tag : His/MBP
Form : Liquid in PBS
Protein length : 1-113 aa
Purity : SDS-PAGE >90%
Applications : WB Positive Control
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP3
Synonyms : CASP3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis related cysteine protease; caspase-3; apopain; CPP32; CPP32B; Yama; CASP-3; CPP-32; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; SCA-1;
Gene ID : 836
mRNA Refseq : NM_004346
Protein Refseq : NP_004337
MIM : 600636
UniProt ID : P42574

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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