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Recombinant Human CBFA2T2 Protein, GST-Tagged

Cat.No. : CBFA2T2-0451H
Product Overview : Human CBFA2T2 full-length ORF (AAH40344, 1 a.a. - 614 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 93.28 kDa
AA Sequence : MGFHHVGQARLELLTSGDLPALASQ RAGITVGPEKRVPAMPGSPVEVKIQ SRSSPPTMPPLPPINPGGPRPVSFT PTALSNGINHSPPTLNGAPSPPQRF SNGPASSTSSALTNQQLPATCGARQ LSKLKRFLTTLQQFGNDISPEIGEK VRTLVLALVNSTVTIEEFHCKLQEA TNFPLRPFVIPFLKANLPLLQRELL HCARAAKQTPSQYLAQHEHLLLNTS IASPADSSELLMEVHGNGKRPSPER REENSFDRDTIAPEPPAKRVCTISP APRHSPALTVPLMNPGGQFHPTPPP LQHYTLEDIATSHLYREPNKMLEHR EVRDRHHSLGLNGGYQDELVDHRLT EREWADEWKHLDHALNCIMEMVEKT RRSMAVLRRCQGSDREELNYWKRRY NENTELRKTGTELVSRQHSPGSADS LSNDSQREFNSRPGTGYVPVEFWKK TEEAVNKVKIQAMSEVQKAVAEAEQ KAFEVIATERARMEQTIADVKRQAA EDAFLVINEQEESTENCWNCGRKAS ETCSGCNIARYCGSFCQHKDWERHH RLCGQNLHGQSPHGQGRPLLPVGRG SSARSADCSVPSPALDKTSATTSRS STPASVTAIDTNGL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 [ Homo sapiens ]
Official Symbol : CBFA2T2
Synonyms : CBFA2T2; core-binding factor, runt domain, alpha subunit 2; translocated to, 2; protein CBFA2T2; MTGR1; ZMYND3; MTG8-like protein; MTG8-related protein 1; ETO homolog on chromosome 20; ETO homologous on chromosome 20; myeloid translocation-related protein 1; myeloid translocation gene-related protein 1; EHT; p85; DKFZp313F2116;
Gene ID : 9139
mRNA Refseq : NM_001032999
Protein Refseq : NP_001028171
MIM : 603672
UniProt ID : O43439

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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